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Generic Name: desirudin (DES i ROO din)
Brand Name: Iprivask
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Drug Information:
Iprivask is an anticoagulant (thrombin inhibitor) that helps prevent the formation of blood clots. Iprivask is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery. This medicine is for use after hip replacement surgery. Iprivask may also be used for purposes not listed in this medication guide. You should not use Iprivask if you have active or uncontrolled bleeding, or an irreversible blood clotting disorder. Learn more

Iprivask Side Effects

Iprivask Side Effects

Note: This document contains side effect information about desirudin. Some of the dosage forms listed on this page may not apply to the brand name Iprivask.

For the Consumer

Applies to desirudin: parenteral powder for injection


    Spinal/Epidural Hematoma Risk
  • Risk of epidural or spinal hematomas and neurologic injury, including long-term or permanent paralysis, associated with concurrent use of selective thrombin inhibitors and neuraxial (spinal/epidural) anesthesia or spinal puncture.

  • Risk increased by use of indwelling epidural catheters for administration of analgesia or by concomitant use of drugs affecting hemostasis (e.g., NSAIAs, platelet aggregation inhibitors, other anticoagulants).

  • Risk also increased by traumatic or repeated epidural or spinal puncture.

  • Monitor frequently for signs and symptoms of neurologic impairment and treat urgently if neurologic compromise noted.

  • Consider potential benefits versus risks of spinal or epidural anesthesia or spinal puncture in patients receiving or being considered for thromboprophylaxis with anticoagulants. (See Hemorrhagic Effects and also see Neurologic Effects under Cautions.)

Side effects include:

Hemorrhage, including hematoma, was most common adverse effect in clinical studies in patients undergoing elective total hip-replacement surgery.

For Healthcare Professionals

Applies to desirudin: subcutaneous powder for injection


The most common adverse reaction was hemorrhage.


Very common (10% or more): Any hemorrhage (30%)

Common (1% to 10%): Serious hemorrhage, deep vein thrombosis

Uncommon (0.1% to 1%): Major hemorrhage

Frequency not reported: Thrombosis, hypotension

Postmarketing reports: Fatal hemorrhage


Common (1% to 10%): Wound secretion

Frequency not reported: Leg edema, fever, healing impaired


Common (1% to 10%): Nausea

Frequency not reported: Vomiting, hematemesis


Common (1% to 10%): Anemia

Frequency not reported: Hemoglobin decreased


Common (1% to 10%): Irritative skin reactions


Common (1% to 10%): Injection site mass


Frequency not reported: Allergic reaction, anti-hirudin antibodies

Postmarketing reports: Anaphylactic/anaphylactoid reaction

Nervous system

Frequency not reported: Dizziness, cerebrovascular disorder


Frequency not reported: Hematuria


Frequency not reported: Leg pain


Frequency not reported: Epistaxis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Iprivask