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Imlygic

Generic Name: talimogene laherparepvec (tal IM oh jeen la HER pa REP vek)
Brand Names: Imlygic
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Drug Information:
Imlygic (talimogene laherparepvec) is a cancer medicine that affects the actions of the body's immune system, helping the body produce an "antitumor" response. Imlygic is a genetically modified weak form of type 1 herpes simplex virus (the virus that causes common cold sores). Imlygic is used to treat a type of cancer called melanoma when it is on the skin or in the lymph glands. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Learn more

Imlygic Side Effects

Imlygic Side Effects

Note: This document contains side effect information about talimogene laherparepvec. Some of the dosage forms listed on this page may not apply to the brand name Imlygic.

For the Consumer

Applies to talimogene laherparepvec: injection suspension

Along with its needed effects, talimogene laherparepvec (the active ingredient contained in Imlygic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking talimogene laherparepvec:

More common

  • Chills
  • cough
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • pain at the injection site
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Break in the skin, especially associated with blue-black discoloration, swelling, or drainage of fluid
  • burning or stinging of the skin
  • painful cold sores or blisters on the lips, nose, eyes, or genitals

Some side effects of talimogene laherparepvec may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • difficulty having a bowel movement (stool)
  • difficulty with moving
  • dizziness
  • muscle pain or stiffness
  • pain in the arms or legs
  • weight loss

For Healthcare Professionals

Applies to talimogene laherparepvec: injectable suspension

General

-The most commonly reported (25% or more) adverse drug reactions were fatigue, chills, pyrexia, nausea, influenza-like illness, and injection site pain.

-Pyrexia, chills, and influenza-like illness can occur at any time during treatment, but were more frequent during the first 3 months.

-Most adverse reactions were mild or moderate in severity and generally resolved within 72 hours.

-Cellulitis was the most common grade 3 or higher adverse reaction.

Other

Very common (10% or more): Fatigue (50.3%), chills (48.6%), pyrexia (42.8%), influenza-like illness (30.5%), injection site pain (27.7%)

Common (1% to 10%): Decreased weight

Frequency not reported: Herpetic infection, injection site complications (cellulitis, systemic bacterial infection, impaired healing)

Gastrointestinal

Very common (10% or more): Nausea (35.6%), vomiting (21.2%), diarrhea (18.8%), constipation (11.6%)

Common (1% to 10%): Abdominal pain

Frequency not reported: Oral herpes

Nervous system

Very common (10% or more): Headache (18.8%)

Common (1% to 10%): Dizziness

Musculoskeletal

Very common (10% or more): Myalgia (17.5%), arthralgia (17.1%), extremity pain (16.4%)

Immunologic

Frequency not reported: Immune-mediated events (glomerulonephritis, vasculitis, pneumonitis, psoriasis, vitiligo)

Oncologic

Frequency not reported: Plasmacytoma

Respiratory

Common (1% to 10%): Oropharyngeal pain

Metabolic

Common (1% to 10%): Decreased weight

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Imlygic