Applies to hydroxocobalamin: intravenous powder for solution
Along with its needed effects, hydroxocobalamin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking hydroxocobalamin:
Incidence not known
Some side effects of hydroxocobalamin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to hydroxocobalamin: compounding powder, injectable solution, intravenous powder for injection
Ventricular extrasystoles, electrocardiogram repolarization abnormality, and heart rate increased were seen in known/suspected cyanide poisoning patients.
Very common (10% or more): Blood pressure increased (28% with 10 gram dose)
Frequency not reported: Increased blood pressure (particularly diastolic), hot flush, ventricular extrasystoles, electrocardiogram repolarization abnormality, heart rate increased
Very common (10% or more): Nausea (11% with 10 gram dose)
Frequency not reported: Dysphagia, abdominal discomfort, vomiting, diarrhea, dyspepsia, hematochezia
Very common (10% or more): Erythema (100% with 10 gram dose), rash (primarily acneiform) (44% with 10 gram dose)
Frequency not reported: Urticaria, pruritus
Very common (10% or more): Chromaturia (red colored urine) (100% with 5 or 10 gram dose), oxalate crystals in urine (61% with 5 gram dose)
Postmarketing reports: Urine calcium oxalate crystals
Very common (10% or more): Lymphocyte count decreased (17% with 10 gram dose)
Very common (10% or more): Infusion site reaction (39% with 10 gram dose)
Postmarketing reports: Acute renal failure with acute tubular necrosis, renal impairment
Very common (10% or more): Headache (33% with 10 gram dose)
Frequency not reported: Memory impairment, dizziness
Pleural effusion was seen in known/suspected cyanide poisoning patients.
Frequency not reported: Dyspnea, throat tightness, dry throat, pleural effusion
Frequency not reported: Allergic reaction
Frequency not reported: Swelling, irritation, redness
Frequency not reported: Peripheral edema, chest discomfort
Frequency not reported: Restlessness
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Hydroxocobalamin