Note: This document contains side effect information about sodium hyaluronate. Some of the dosage forms listed on this page may not apply to the brand name Hyalgan.
Applies to sodium hyaluronate: injection gel/jelly, injection solution
Along with its needed effects, sodium hyaluronate (the active ingredient contained in Hyalgan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking sodium hyaluronate:
Some side effects of sodium hyaluronate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to sodium hyaluronate: intra-articular solution
Common (1% to 10%): Injection site pain/swelling/effusion/redness/warmth
Uncommon (0.1% to 1%):
Frequency not reported: Hayfever reaction on face and neck, reaction on forearms and knees
Postmarketing reports: Anaphylaxis/anaphylactoid reaction
Frequency not reported: Swelling of the face/eyelids/mouth/extremities, fever
Common (1% to 10%): Nausea, vomiting, abdominal pain, diarrhea, dyspepsia
Frequency not reported: Transient hypotension
Very common (10% or more): Arthralgia (18%), arthropathy/arthrosis/arthritis (11%)
Common (1% to 10%): Back pain, leg discomfort, leg pain
Common (1% to 10%): Influenza-like reaction
Common (1% to 10%): Urinary tract infection
Common (1% to 10%): Upper respiratory tract infection, sinusitis, bronchitis, rhinitis
Common (1% to 10%): Headache, dizziness
Frequency not reported: Rash, itching
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Hyalgan