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Generic Name: methenamine (meh THEH na meen)
Brand Name: Hiprex
Physician reviewed Hiprex patient information - includes Hiprex description, dosage and directions.
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Drug Information:
Hiprex is an antibiotic that is used to prevent recurring bladder infections from coming back. This medicine is used in adults and children at least 6 years old. Hiprex is usually given after other antibiotics have been given to treat the initial infection. Hiprex may also be used for purposes not listed in this medication guide. You should not use Hiprex if you have kidney disease, severe liver disease, if you also take a sulfa drug, or if you are dehydrated. You should not use Hiprex if you are allergic to it, or if you have: Learn more

Hiprex Side Effects

Hiprex Side Effects

Note: This document contains side effect information about methenamine. Some of the dosage forms listed on this page may not apply to the brand name Hiprex.

For the Consumer

Applies to methenamine: oral tablet

Along with its needed effects, methenamine (the active ingredient contained in Hiprex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methenamine:

Less common

  • Skin rash


  • Blood in urine
  • lower back pain
  • pain or burning while urinating

Some side effects of methenamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Nausea and vomiting

For Healthcare Professionals

Applies to methenamine: compounding powder, oral suspension, oral tablet


This drug was generally well tolerated. Minor side effects have been reported in less than 3.5% of patients and were reversible when the drug was stopped.


Uncommon (0.1% to 1%): Rash, pruritus

Frequency not reported: Generalized skin rash


Uncommon (0.1% to 1%): Gastric irritation

Frequency not reported: Nausea, vomiting, upset stomach, stomatitis, gastrointestinal disturbances, diarrhea, abdominal cramping


High doses have been associated with albuminuria, gross hematuria, bladder irritation, and painful/frequent micturition.

Uncommon (0.1% to 1%): Bladder irritation

Frequency not reported: Dysuria, hematuria, urinary frequency, albuminuria


Frequency not reported: Elevated AST, elevated ALT


Frequency not reported: Hypersensitivity reactions


Frequency not reported: Anorexia


Frequency not reported: Anterior uveitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Hiprex