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Generic Name: haemophilus b conjugate (PRP-T) vaccine (hem OFF il us B KON ju gate)
Brand Names: ActHIB, Hiberix
Hiberix vaccine is used to prevent infection caused by haemophilus B bacteria. Learn about side effects, interactions and indications.
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Drug Information:
Hiberix is a brand of haemophilus B vaccine. Haemophilus influenzae type B (Hib) is a type of influenza (flu) caused by bacteria. Haemophilus B influenzae bacteria can infect the lungs or throat, and can also spread to the blood, bones, joints, brain, or spinal cord. The bacteria infection can cause breathing problems or meningitis, and these infections can be fatal. Hiberix is used to prevent haemophilus B in children, and is sometimes combined with vaccines to protect against other diseases. Hiberix is given to children between the ages of 2 months and 18 months old. Learn more

Hiberix Side Effects

Hiberix Side Effects

Note: This document contains side effect information about haemophilus b conjugate (prp-t) vaccine. Some of the dosage forms listed on this page may not apply to the brand name Hiberix.

For the Consumer

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for solution, intramuscular powder for suspension, intramuscular solution

Along with its needed effects, haemophilus b conjugate (prp-t) vaccine (the active ingredient contained in Hiberix) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking haemophilus b conjugate (prp-t) vaccine:

More common

  • Diarrhea
  • loss of appetite
  • vomiting

Less common

  • Earache
  • redness or swelling in the ear


  • Chest pain
  • chills
  • convulsions (seizures)
  • cough
  • fever over 102 degrees F (39 degrees C)
  • lack or loss of strength
  • shortness of breath
  • sneezing
  • sore throat
  • tightness in the chest
  • troubled breathing
  • wheezing

Incidence not known

  • Bluish lips or skin
  • dizziness
  • fast heartbeat
  • hives
  • itching (especially of the feet or hands)
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • reddening of the skin (especially around the ears)
  • skin rash
  • swelling of the eyes, face, or inside of the nose
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • unusual tiredness or weakness (sudden and severe)

Some side effects of haemophilus b conjugate (prp-t) vaccine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Fever less than 102 degrees F (39 degrees C)
  • irritability
  • redness, pain, swelling, tenderness, or warm feeling at the injection site
  • reduced physical activity
  • restlessness
  • sleepiness

Less common

  • Prolonged crying lasting more than 4 hours
  • unusual high-pitched crying

Incidence not known

  • Hives or welts
  • sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to haemophilus b conjugate (prp-t) vaccine: intramuscular powder for injection


The most common adverse events were pain and redness at the injection site, irritability, drowsiness, fever, loss of appetite, fussiness, and restlessness. Most symptoms occur in the first 48 hours, are mild, and resolve spontaneously.


Very common (10% or more): Pain (49.4%), redness (29.4%), tenderness (20%), swelling (18.7%)

Common (1% to 10%): Induration

Very rare (less than 0.01%): Extensive swelling of vaccinated limb, injection site induration

Nervous system

Very common (10% or more): Drowsiness (59.9%), decreased activity/lethargy (51.1%), sleepiness (19.9%)

Rare (less than 0.1%): Seizure with apnea, convulsion

Very rare (less than 0.01%): Convulsions (with or without fever), hypotonic-hyporesponsive episode (e.g. sudden onset of hypotonia, hyporesponsiveness, and pallor or cyanosis), somnolence, syncope, vasovagal responses to injection


Very common (10% or more): Irritability (70.4%), fussiness (25.9%), restlessness (21.8%)

Common (1% to 10%): Nervousness

Uncommon (0.1% to 1%): Emotional lability, insomnia


Very common (10% or more): Inconsolable crying (58.5%), fever (34.8%)

Common (1% to 10%): Otitis media

Uncommon (0.1% to 1%): Asthenia, fatigue, injury

Postmarketing reports: Peripheral edema


Very common (10% or more): Loss of appetite (28.7%)


Very common (10% or more): Diarrhea (14.6%), vomiting

Common (1% to 10%): Gastroenteritis

Uncommon (0.1% to 1%): Abdominal pain


Common (1% to 10%): Rash erythematous

Uncommon (0.1% to 1%): Sweating increased, purpura

Very rare (less than 0.01%): Angioedema, rash, urticaria

Postmarketing reports: Pruritus


Common (1% to 10%): Rhinitis, coughing, respiratory disorder, upper respiratory tract infection, bronchitis

Rare (less than 0.1%): Bilateral pneumonia

Very rare (less than 0.01%): Apnea in very premature infants


Rare (less than 0.1%): Allergic reactions (including anaphylactic and anaphylactoid reactions)

Postmarketing reports: Other allergic/hypersensitivity reactions (including urticaria, angioedema)


Uncommon (0.1% to 1%): Spastic paralysis


Common (1% to 10%): Conjunctivitis


Common (1% to 10%): Viral infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Hiberix