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Generic Name: tasimelteon (TAS i MEL tee on)
Brand Names: Hetlioz
Hetlioz (tasimelteon) is used to treat Non-24 Hour Sleep-Wake Disorder. Includes Hetlioz side effects, interactions and indications.
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Drug Information:
Hetlioz (tasimelteon) is a sedative, also called a hypnotic. It works by affecting certain substances in your body that help regulate your "sleep-wake cycle." Hetlioz is used to treat non-24-hour sleep-wake disorder. Hetlioz may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Hetlioz if you are allergic to tasimelteon. Learn more

Hetlioz Side Effects

Hetlioz Side Effects

Note: This document contains side effect information about tasimelteon. Some of the dosage forms listed on this page may not apply to the brand name Hetlioz.

For the Consumer

Applies to tasimelteon: oral capsule

Along with its needed effects, tasimelteon (the active ingredient contained in Hetlioz) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tasimelteon:

More common

  • Bladder, lower back, or side pain
  • bloody or cloudy urine
  • difficult, burning, frequent, or painful urination

Some side effects of tasimelteon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • chills or fever
  • cough
  • ear congestion
  • headache
  • nasal congestion, runny nose, or sneezing
  • nightmares

For Healthcare Professionals

Applies to tasimelteon: oral capsule

Nervous system

Very common (10% or more): Headache (17%)

Frequency not reported: Somnolence


Very common (10% or more): Increased ALT (10%)


Very common (10% or more): Nightmare/abnormal dreams (10%)


Common (1% to 10%): Urinary tract infection


Common (1% to 10%): Upper respiratory tract infection

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Hetlioz