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Generic Name: miglitol (MIG li tol)
Brand Name: Glyset
Physician reviewed Glyset patient information - includes Glyset description, dosage and directions.
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Drug Information:
Glyset delays the digestion of carbohydrates (forms of sugar) in your body. This decreases the amount of sugar that passes into your blood after a meal and prevents periods of hyperglycemia (high blood sugar). Glyset is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes. Glyset may also be used for purposes not listed in this medication guide. You should not use Glyset if you have inflammatory bowel disease (ulcerative colitis, Crohn's), a blockage in your intestines, a chronic intestinal disorder that affects digestion, or a stomach disorder that causes excess gas. Do not take this medicine if you are in a state of diabetic ketoacidosis. Learn more

Glyset Side Effects

Glyset Side Effects

Note: This document contains side effect information about miglitol. Some of the dosage forms listed on this page may not apply to the brand name Glyset.

In Summary

Common side effects of Glyset include: abdominal pain, diarrhea, gastrointestinal signs and symptoms, and flatulence. Other side effects include: decreased serum iron, and skin rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to miglitol: oral tablet

Some side effects of miglitol (the active ingredient contained in Glyset) may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bloated full feeling
  • excess air or gas in stomach or intestines
  • increase in bowel movements
  • loose stools
  • passing gas
  • soft stools
  • stomach or abdomen pain

Less common

  • Skin rash

For Healthcare Professionals

Applies to miglitol: oral tablet


The most commonly reported adverse reactions include gastrointestinal symptoms; they tend to diminish in frequency and intensity with time.


Very common (10% or more): Flatulence (41.5%), diarrhea (28.7%), abdominal pain (11.7%)

Postmarketing reports: Pneumatosis cystoides intestinalis (may present with symptoms of diarrhea, mucus discharge, rectal bleeding, and constipation), ileus (including paralytic ileus), subileus, gastrointestinal pain, nausea, abdominal distention.

The severity of gastrointestinal symptoms may be decreased by dosage reduction and avoiding high gas-producing foods and sucrose. Some studies have demonstrated a decrease in the severity of gastrointestinal effects over time with continued administration.


Common (1% to 10%): Skin rash


Common (1% to 10%): Low serum iron

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Glyset