Applies to glipizide: oral tablet, oral tablet extended release
Along with its needed effects, glipizide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glipizide:
Incidence not known
Some side effects of glipizide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to glipizide: compounding powder, oral tablet, oral tablet extended release
The more commonly reported side effects have included dizziness, diarrhea, nervousness, tremor, hypoglycemia, and flatulence.
Disulfiram-like reactions have been reported with sulfonylureas. Clinical experience has shown this drug to have a low incidence of disulfiram-like alcohol reactions.
Common (1% to 10%): Hypoglycemia
Uncommon (less than 1%): Thirst
Frequency not reported: Disulfiram like reactions, hepatic porphyria, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), elevation of LDH
Frequency not reported: Leucopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, pancytopenia
Common (1% to 10%): Syncope
Uncommon (less than 1%): Arrhythmia, flushing, hypertension
Frequency not reported: Impaired hepatic function, hepatitis, jaundice, mild to moderate ALT, LDH, alkaline phosphatase elevations
Postmarketing reports: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice
Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas.
Common (1% to 10%): Sweating, pruritus
Uncommon (less than 1%): Rash, urticaria
Frequency not reported: Rash, erythema, morbilliform or maculopapular eruptions, urticaria, pruritus, eczema
Common (1% to 10%): Nausea, diarrhea, constipation, gastralgia, vomiting, flatulence, dyspepsia
Uncommon (less than 1%): Anorexia, trace blood in stool
Frequency not reported: Gastrointestinal irritation, gastrointestinal bleeding
Postmarketing reports: Abdominal pain
Gastrointestinal side effects appear to be dose-related and may disappear on division or reduction of dosage.
Common (1% to 10%): Polyuria
Uncommon (less than 1%): Dysuria
Common (1% to 10%): Arthralgia, leg cramps, myalgia
Common (1% to 10%): Headache, dizziness, nervousness, tremors, paresthesia, hypesthesia
Uncommon (less than 1%): Migraine
Frequency not reported: Drowsiness
Common (1% to 10%): Blurred vision
Uncommon (less than 1%): Pain in the eye, conjunctivitis, retinal hemorrhage
Frequency not reported: Diplopia, abnormal vision, visual impairment, decreased vision
Common (1% to 10%): Asthenia, pain
Uncommon (less than 1%): Chills, edema
Frequency not reported: Vertigo, malaise
Common (1% to 10%): Insomnia, anxiety, depression
Frequency not reported: Confusion
Common (1% to 10%): Rhinitis
Uncommon (less than 1%): Pharyngitis, dyspnea
Frequency not reported: Mild to moderate BUN and creatinine elevations
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Glipizide Xl