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Generic Name: teduglutide (TE due GLOO tide)
Brand Names: Gattex
Gattex (teduglutide) is used to treat short bowel syndrome. Includes Gattex side effects, interactions and indications.
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Drug Information:
Gattex (teduglutide) is a man-made form of an amino acid that affects the processes of growth and function of cells in the stomach and intestines. Gattex is a prescription medicine used to treat short bowel syndrome in adults and pediatric patients one year of age and older who depend on intravenous (parenteral) feeding to receive nutrition. You should not use Gattex if you are allergic to teduglutide, or if you have cancer of the stomach, intestines, liver, gallbladder, or pancreas. Before using Gattex, tell your doctor if you have heart disease, kidney disease, intestinal polyps, a blockage in your stomach or intestines, a colostomy or ileostomy, or a history of gallbladder or pancrease problems. Learn more

Gattex Side Effects

Gattex Side Effects

Note: This document contains side effect information about teduglutide. Some of the dosage forms listed on this page may not apply to the brand name Gattex.

For the Consumer

Applies to teduglutide: subcutaneous powder for solution

Along with its needed effects, teduglutide (the active ingredient contained in Gattex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking teduglutide:

More common

  • Decrease in the amount of urine
  • excess air or gas in the stomach or bowels
  • fast heartbeat
  • fever
  • full or bloated feeling
  • hives, itching, skin rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • noisy, rattling breathing
  • pressure in the stomach
  • redness of the skin
  • stomach pain
  • swelling of the abdominal or stomach area
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing at rest
  • troubled breathing or swallowing
  • weight gain

Less common

  • Indigestion
  • severe nausea or vomiting

Incidence not known

  • Blurred vision
  • chest pain or discomfort
  • dilated neck veins
  • extreme tiredness or weakness
  • inability to speak
  • irregular breathing
  • irregular heartbeat
  • loss of consciousness
  • no blood pressure or pulse
  • seizures
  • severe or sudden headache
  • slurred speech
  • stopping of the heart
  • temporary blindness
  • weakness in the arm or leg on one side of the body, sudden and severe

Some side effects of teduglutide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • changes in appetite
  • chills
  • cough
  • ear congestion
  • headache
  • loss of voice
  • nasal congestion
  • nausea
  • runny nose
  • sneezing
  • sore throat
  • trouble sleeping
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to teduglutide: subcutaneous kit


The most commonly reported side effects included anti-teduglutide (the active ingredient contained in Gattex) antibody formation, gastrointestinal stoma complication, abdominal pain, and injection site reactions.


Very common (10% or more): Anti-teduglutide (the active ingredient contained in Gattex) antibody formation (up to 48%)

Common (1% to 10%): Influenza, influenza-like illness


GI stoma complication (swelling of the stoma and associated complications) is considered a sign of efficacy rather than an adverse event.

Very common (10% or more): Abdominal pain and distention (up to 45%), gastrointestinal stoma complication (up to 41.9%), abdominal pain (up to 37.7%), nausea (up to 26%), abdominal distention (up to 19.5%), vomiting (up to 14%)

Common (1% to 10%): Colonic polyp, colonic stenosis, diarrhea, flatulence, intestinal obstruction, intestinal stenosis, pancreatic duct stenosis, pancreatitis, small intestinal stenosis, upper abdominal pain

Uncommon (0.1% to 1%):

Frequency not reported: Acute pancreatitis, chronic pancreatitis, painful defecation, pancreatic pseudocyst


Very common (10% or more): Injection site reactions (up to 26%), injection site hematoma (up to 11%)

Common (1% to 10%): injection site erythema

Frequency not reported: Injection site hemorrhage, injection site pain, injection site swelling


Very common (10% or more): Respiratory tract infections (up to 28%), upper respiratory tract infection (up to 26%), nasopharyngitis (up to 13%)

Common (1% to 10%): Cough, dyspnea

Frequency not reported: Lower respiratory tract infection

Nervous system

Very common (10% or more): Headache (up to 16%)

Uncommon (0.1% to 1%): Syncope

Frequency not reported: Coma, mental status deterioration

Postmarketing reports: Cerebral hemorrhage, dizziness


Very common (10% or more): Urinary tract infection (up to 13%)

Common (1% to 10%): Catheter related infection, catheter sepsis


Very common (10% or more): Fluid overload (up to 11.7%)

Common (1% to 10%): Appetite disorders, decreased appetite


Common (1% to 10%): Anxiety, insomnia, sleep disturbances


Common (1% to 10%): Cholecystitis, cholecystitis acute

Frequency not reported: Cholelithiasis, cholestasis, gallbladder perforation


Common (1% to 10%): Cardiac/congestive failure congestive, peripheral edema

Frequency not reported: Cardiac dysfunction

Postmarketing reports: Cardiac arrest, cardiac failure


Common (1% to 10%): Fatigue, pyrexia

Frequency not reported: C-reactive protein


Common (1% to 10%): Colorectal polyps

Uncommon (0.1% to 1%): Duodenal polyp, hyperplastic sigmoidal polyps, inflammatory stomal polyps

Frequency not reported: Gastric polyp, malignancy, metastatic adenocarcinoma, non-small cell lung cancer, squamous cell lung cancer


Common (1% to 10%): Skin hemorrhage


Common (1% to 10%): Arthralgia


Common (1% to 10%): Hypersensitivity


Frequency not reported: Undiagnosed hypothyroidism

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Gattex