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Generic Name: degarelix (DEG a REL ix)
Brand Names: Firmagon
Firmagon (degarelix) treats advanced prostate cancer by decreasing the amount of testosterone in the body. Includes Firmagon side effects, interactions and indications.
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Drug Information:
Firmagon (degarelix) is a man-made form of a protein that reduces the amount of certain hormones in the body, including testosterone. Firmagon injection is used to treat prostate cancer. It works by decreasing the amount of testosterone in the body, which the tumor needs to grow. It is not known if Firmagon is safe or effective in children. Although Firmagon is not for use by women, degarelix should not be used by a woman who is pregnant or breast-feeding, or who may become pregnant. Before you receive Firmagon, tell your doctor if you have liver or kidney disease, a personal or family history of "Long QT syndrome," congestive heart failure, or an electrolyte imbalance, such as low or high levels of potassium or magnesium in your blood. Learn more

Firmagon Side Effects

Firmagon Side Effects

Note: This document contains side effect information about degarelix. Some of the dosage forms listed on this page may not apply to the brand name Firmagon.

For the Consumer

Applies to degarelix: subcutaneous powder for solution

Along with its needed effects, degarelix (the active ingredient contained in Firmagon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking degarelix:

More common

  • Back pain
  • blurred vision
  • dizziness
  • fever
  • flushing or redness of the skin
  • hard lump
  • headache
  • nervousness
  • pain
  • pounding in the ears
  • slow or fast heartbeat
  • small lumps under the skin
  • swelling
  • unusually warm skin

Less common

  • Bladder pain
  • bloody or cloudy urine
  • chills
  • decrease in testicle size
  • decreased interest in sexual intercourse
  • difficult, burning, or painful urination
  • difficulty in moving
  • frequent urge to urinate
  • inability to have or keep an erection
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • lower back or side pain
  • muscle pain or stiffness
  • pain in the joints


  • Chest pain or discomfort
  • fainting
  • irregular heartbeat
  • pounding heartbeat
  • shortness of breath

Some side effects of degarelix may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • feeling of warmth
  • increased weight
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • unusual tiredness or weakness

Less common

  • Diarrhea
  • lack or loss of strength
  • nausea
  • night sweats
  • sleeplessness
  • swelling of the breasts or breast soreness
  • trouble sleeping
  • unable to sleep

For Healthcare Professionals

Applies to degarelix: subcutaneous powder for injection


Very common (10% or more): Increased liver transaminases (47%), increased gamma-glutamyltransferase (10%)

Uncommon (0.1% to 1%): Increased bilirubin, increased alkaline phosphatase


Very common (10% or more): Injection site reaction (including pain, erythema, swelling, induration, nodule; 44%), pyrexia (10%), fatigue (10%)

Common (1% to 10%): Chills, asthenia, influenza-like illness


Very common (10% or more): Decreased hematocrit (40%), decreased hemoglobin (15%)

Common (1% to 10%): Anemia

Rare (less than 0.1%): Neutropenic fever


Very common (10% or more): Hot flush (26%), QT/QTc interval prolongation (20%)

Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Cardiac arrhythmia (including atrial fibrillation), palpitations, vasovagal reaction (including hypotension)

Rare (less than 0.1%): Myocardial infarction, cardiac failure


Very common (10% or more): Abnormal BUN (15%)

Common (1% to 10%): Abnormal creatinine level

Uncommon (0.1% to 1%): Renal impairment


Very common (10% or more): Increased weight (11%), decreased weight (10%)

Common (1% to 10%): Abnormal potassium level

Uncommon (0.1% to 1%): Hyperglycemia/diabetes mellitus, increased cholesterol, decreased appetite, blood calcium changes


Very common (10% or more): Antibody formation (10%)


Common (1% to 10%): Hyperhidrosis (including night sweats), rash

Uncommon (0.1% to 1%): Urticaria, skin hyperpigmentation, skin nodule, alopecia, pruritus, erythema


Common (1% to 10%): Nausea, constipation, diarrhea

Uncommon (0.1% to 1%): Vomiting, abdominal pain, abdominal discomfort, dry mouth


Common (1% to 10%): Urinary tract infection, gynecomastia, testicular atrophy, erectile dysfunction

Uncommon (0.1% to 1%): Pollakiuria, micturition urgency, dysuria, nocturia, incontinence, testicular pain, breast pain, pelvic pain, genital irritation, ejaculation failure


Common (1% to 10%): Back pain, arthralgia, musculoskeletal pain and discomfort

Uncommon (0.1% to 1%): Osteoporosis/osteopenia, arthralgia, muscular weakness, muscle spasms, joint swelling/stiffness

Nervous system

Common (1% to 10%): Dizziness, headache

Uncommon (0.1% to 1%): Mental impairment, hypoesthesia


Common (1% to 10%): Insomnia

Uncommon (0.1% to 1%): Loss of/decreased libido, depression


Uncommon (0.1% to 1%): Hypersensitivity reaction

Postmarketing reports: Anaphylaxis, angioedema


Uncommon (0.1% to 1%): Blurred vision


Uncommon (0.1% to 1%): Dyspnea

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Firmagon