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Generic Name: icatibant (eye KAT i bant)
Brand Names: Firazyr
Firazyr (icatibant) is used to treat hereditary angioedema. Includes Firazyr side effects, interactions and indications.
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Drug Information:
Firazyr (icatibant) is used to treat attacks of hereditary angioedema (an immune system disorder) in adults. Firazyr is not a cure for hereditary angioedema. Firazyr may also be used for purposes not listed in this medication guide. You should not use Firazyr if you are allergic to icatibant. To make sure you can safely use this medicine, tell your doctor about all of your medical conditions, if you use heart or blood pressure medications, and if you are pregnant or breast-feeding. Get emergency medical help if you have any swelling of your tongue or throat during an angioedema attack. Learn more

Firazyr Side Effects

Firazyr Side Effects

Note: This document contains side effect information about icatibant. Some of the dosage forms listed on this page may not apply to the brand name Firazyr.

In Summary

Common side effects of Firazyr include: hematoma at injection site, injection site reaction, urticaria at injection site, bruising at injection site, burning sensation at injection site, erythema at injection site, irritation at injection site, pain at injection site, and swelling at injection site. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to icatibant: subcutaneous solution

Along with its needed effects, icatibant (the active ingredient contained in Firazyr) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking icatibant:

Less common

  • Fever

Some side effects of icatibant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

Less common

  • Dizziness

Incidence not known

  • Headache
  • nausea
  • rash

For Healthcare Professionals

Applies to icatibant: subcutaneous solution


The most common adverse reactions were injection site reactions, pyrexia, transaminase increased, dizziness, and rash.


Injection site reaction includes bruising, hematoma, burning, erythema, hypoesthesia, irritation, numbness, edema, pain, pressure sensation, pruritus, swelling, urticaria, or warmth at the site of injection.

Very common (10% or more): Injection site reaction (97%)


Common (1% to 10%): Rash, pruritus, erythema

Uncommon (0.1% to 1%): Generalized urticaria


Common (1% to 10%): Nasopharyngitis, nasal congestion

Uncommon (0.1% to 1%): Pharyngitis, asthma, cough


Common (1% to 10%): Gastroenteritis, nausea

Uncommon (0.1% to 1%): Vomiting

Nervous system

Common (1% to 10%): Dizziness, headache


Common (1% to 10%): Pyrexia

Uncommon (0.1% to 1%): Asthenia, fatigue, contusion


Common (1% to 10%): Transaminase increased

Uncommon (0.1% to 1%): Liver function test abnormal


Common (1% to 10%): Prothrombin time prolonged


Common (1% to 10%): Blood creatinine phosphokinase increased


Uncommon (0.1% to 1%): Weight increased, blood glucose increased, hyperuricemia, hyperglycemia


Uncommon (0.1% to 1%): Herpes zoster

Frequency not reported: Anti-icatibant (the active ingredient contained in Firazyr) antibodies


Uncommon (0.1% to 1%): Hot flush


Uncommon (0.1% to 1%): Proteinuria


Uncommon (0.1% to 1%): Muscle spasm

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Firazyr