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Generic Name: aspirin, butalbital, and caffeine (AS pir in, byoo TAL bi tal, KAF een)
Brand Names: Butalbital Compound, Fiorinal
Fiorinal (aspirin, butalbital, and caffeine) is used to treat tension headaches. Includes Fiorinal side effects, interactions and indications.
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Drug Information:
Fiorinal contains a combination of aspirin, butalbital, and caffeine. Aspirin is a pain reliever, as well as an anti-inflammatory and a fever reducer. Butalbital is a barbiturate. It relaxes muscle contractions involved in a tension headache. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow. Fiorinal is used to treat tension headaches. This medicine is not for treating headaches that come and go. Fiorinal may also be used for purposes not those listed in this medication guide. Learn more

Fiorinal Side Effects

Fiorinal Side Effects

Note: This document contains side effect information about aspirin / butalbital / caffeine. Some of the dosage forms listed on this page may not apply to the brand name Fiorinal.

For the Consumer

Applies to aspirin / butalbital / caffeine: oral capsule, oral tablet

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of bleeding like throwing up or coughing up blood; vomit that looks like coffee grounds; blood in the urine; black, red, or tarry stools; bleeding from the gums; abnormal vaginal bleeding; bruises without a cause or that get bigger; or bleeding you cannot stop.
  • Very bad belly pain.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Feeling sleepy.
  • Dizziness.
  • Belly pain or heartburn.
  • Upset stomach.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to aspirin/butalbital/caffeine: oral capsule, oral tablet


The most common adverse reactions have included drowsiness and dizziness.

Nervous system

Common (1% to 10%): Drowsiness, dizziness

Frequency not reported: Lightheadedness


Frequency not reported: Nausea, vomiting, flatulence


Frequency not reported: bone marrow suppression


Postmarketing reports: Allergic reaction, anaphylactic shock


Frequency not reported: toxic epidermal necrolysis, erythema multiforme

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Fiorinal