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Fetzima

Generic Name: levomilnacipran (LEE voe mil NA si pran)
Brand Names: Fetzima
Fetzima (levomilnacipran) is used to treat major depressive disorder. Includes Fetzima side effects, interactions and indications.
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Drug Information:
Fetzima (levomilnacipran) is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI). Levomilnacipran affects chemicals in the brain that may be unbalanced in people with depression. Fetzima is used to treat major depressive disorder. A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia. You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma. Learn more

Fetzima Side Effects

Fetzima Side Effects

Note: This document contains side effect information about levomilnacipran. Some of the dosage forms listed on this page may not apply to the brand name Fetzima.

In Summary

Common side effects of Fetzima include: erectile dysfunction, nausea, and orthostatic hypotension. Other side effects include: constipation, ejaculatory disorder, epididymitis, increased heart rate, palpitations, premature ejaculation, sinus tachycardia, tachycardia, testicular pain, urinary hesitancy, vomiting, delayed ejaculation, ejaculation failure, and hyperhidrosis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to levomilnacipran: oral capsule extended release

Warning

Oral route (Capsule, Extended Release)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults; however, this risk was not observed in patients older than 24 years and risk was reduced in patients 65 years or older. Closely monitor patients of all ages for clinical worsening and for emergence of suicidal thoughts and behaviors. Not approved for use in pediatric patients.

Along with its needed effects, levomilnacipran (the active ingredient contained in Fetzima) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking levomilnacipran:

More common

  • Difficult urination
  • fast, pounding, or irregular heartbeat or pulse

Less common

  • Anxiety
  • arm, back, or jaw pain
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or discomfort
  • chest tightness or heaviness
  • cloudy urine
  • confusion
  • decrease in the frequency of urination
  • difficulty in passing urine (dribbling)
  • difficulty with speaking
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drooling
  • dry mouth
  • fainting
  • headache
  • irritability
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • nausea
  • painful urination
  • pounding in the ears
  • rapid or irregular heartbeat
  • restlessness
  • shaking
  • shortness of breath
  • shuffling walk
  • slow heartbeat
  • stiffness of the limbs
  • sweating
  • trouble sleeping
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back
  • unusual tiredness or weakness

Some side effects of levomilnacipran may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty having a bowel movement (stool)
  • increased sweating
  • loss in sexual ability, desire, drive, or performance
  • vomiting

Less common

  • Abdominal or stomach pain
  • bloated or full feeling
  • decreased appetite
  • dry eyes
  • dry skin
  • feeling of warmth
  • headache, severe and throbbing
  • hives or welts, itching, or rash
  • passing gas
  • red eye
  • red face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • thirst
  • yawning

For Healthcare Professionals

Applies to levomilnacipran: oral capsule extended release

General

The most commonly reported side effects were nausea, erectile dysfunction, constipation, and hyperhidrosis.

Gastrointestinal

Very common (10% or more): Nausea (up to 17%)

Common (1% to 10%): Constipation, vomiting

Frequency not reported: Abdominal pain, flatulence

Genitourinary

Common (1% to 10%): Erectile dysfunction, ejaculation disorder, testicular pain, urinary hesitation

Frequency not reported: Delayed ejaculation, ejaculation failure, epididymitis, hematuria, organic erectile dysfunction, pollakiuria, premature ejaculation, proteinuria, psychogenic erectile dysfunction, seminal vesiculitis, testicular pain, urinary retention

Cardiovascular

Common (1% to 10%): Hot flush, hypertension, hypotension, increased blood pressure, increased heart rate, palpitations, tachycardia

Frequency not reported: Angina pectoris, chest pain, increased orthostatic blood pressure, increased orthostatic heart rate response, increased systolic/diastolic blood pressure, labile hypertension, orthostatic hypotension, postural orthostatic tachycardia syndrome, sinus tachycardia, supraventricular and ventricular extra systoles

Dermatologic

Common (1% to 10%): Hyperhidrosis, rash

Frequency not reported: Dry skin, erythematous rash, generalized rash, macular rash, maculopapular rash, pruritus, urticaria

Metabolic

Common (1% to 10%): Decreased appetite

Frequency not reported: Hyponatremia, increased blood cholesterol, thirst

Psychiatric

Frequency not reported: Activation of mania/hypomania, aggression, agitation, anger, bruxism, discontinuation syndrome, panic attack, suicidal thought and behaviors in adolescents and young adults, tension

Nervous system

Frequency not reported: Extrapyramidal disorder, migraine, paresthesia, postural dizziness, seizure, serotonin syndrome, syncope

Ocular

Frequency not reported: Angle closure glaucoma, blurred vision, conjunctival hemorrhage, dry eye

Hypersensitivity

Frequency not reported: Hypersensitivity

Hematologic

Frequency not reported: Abnormal bleeding

Hepatic

Frequency not reported: Abnormal liver function test

Respiratory

Frequency not reported: Yawning

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Fetzima