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Generic Name: famciclovir (fam SYE klo veer)
Brand Name: Famvir
Physician reviewed famciclovir patient information - includes famciclovir description, dosage and directions.
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Drug Information:
Famciclovir is an antiviral medicine that is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles. Famciclovir is sometimes used in people with human immunodeficiency virus (HIV) who develop herpes outbreaks around the mouth, genitals, or anal area. Famciclovir may not be effective in treating your first episode of genital herpes, but may help prevent future episodes. Famciclovir also may not be effective in Black or African-American people with genital herpes, and may not be effective in any person with shingles (herpes zoster) affecting the eyes. Learn more

Famciclovir Side Effects

Famciclovir Side Effects

In Summary

Commonly reported side effects of famciclovir include: headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to famciclovir: oral tablet

Along with its needed effects, famciclovir may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking famciclovir:

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • blood in urine or stools
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • dizziness
  • fever
  • joint or muscle pain
  • loss of appetite
  • pinpoint red spots on the skin
  • red, irritated eyes
  • sore throat
  • sores, ulcers, or white spots in the mouth or on the lips
  • unpleasant breath odor
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

Some side effects of famciclovir may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cramps
  • diarrhea
  • headache
  • heavy bleeding
  • nausea
  • stomach pain

Less common

  • Bloated, full feeling
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feeling
  • confusion as to time, place, or person
  • excess air or gas in the stomach or intestines
  • hives or welts
  • holding false beliefs that cannot be changed by fact
  • itching skin
  • mood or mental changes
  • passing gas
  • rash
  • redness of skin
  • seeing, hearing, or feeling things that are not there
  • unusual excitement, nervousness, or restlessness
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Sleepiness or unusual drowsiness

For Healthcare Professionals

Applies to famciclovir: oral tablet


Famciclovir is generally well tolerated. The most common side effects reported in at least 1 indication by greater than 10% of patients are headache and nausea.

Nervous system

Very common (10% or more): Headache (up to 39.3%)

Common (1% to 10%): Migraine (up to 3.1%), paresthesia (up to 2.6%)

Frequency not reported: Insomnia

Postmarketing reports: Dizziness, somnolence

Confusion and bradykinesia developed in an 80-year-old woman who received famciclovir for acute herpes zoster. The dosage administered was clinically appropriate and adjusted to her estimated creatinine clearance. Although herpes zoster may sometimes elicit neurological complications and cannot be ruled out as a contributing factor, the patient's mobility problems and mental deterioration corresponded temporally with drug administration (onset within 48 and 72 hours, respectively, of initiation and reinstitution of therapy).


An isolated case of acute necrotic-hemorrhagic pancreatitis occurred in a kidney graft recipient who was treated with famciclovir for severe hepatitis B infection. The author could not identify any other etiologic factor for the pancreatitis, although some possible predisposing factors were noted, including the patient's liver insufficiency and renal dysfunction.

Very common (10% or more): Nausea (up to 13%)

Common (1% to 10%): Diarrhea (up to 9%), abdominal pain (up to 7.9%), vomiting (up to 5%), elevated lipase (greater than 1.5 times normal range high [NRH]; 4.9%), flatulence (up to 4.8%), elevated amylase (greater than 1.5 times NRH; 1.5%)

Rare (less than 0.1%): Pancreatitis

Frequency not reported: Dyspepsia, anorexia


Common (1% to 10%): Dysmenorrhea (up to 7.6%)


Common (1% to 10%): Fatigue (up to 4.8%)

Frequency not reported: Injury, back pain, viral infection (including influenza, influenza-like symptoms, and symptoms of a cold), asthenia, fever


Common (1% to 10%): Pruritus (up to 3.7%), rash (up to 3.3%)

Postmarketing reports: Urticaria, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema (e.g., face, eyelid, periorbital, and pharyngeal edema), leukocytoclastic vasculitis


Common (1% to 10%): Neutropenia (less than 0.8 times normal range low [NRL]; 3.2%), leukopenia (less than 0.75 times NRL; 1.3%)

Uncommon (0.1% to 1%): Anemia (less than 0.8 times NRL; 0.1%)

Postmarketing reports: Thrombocytopenia


Common (1% to 10%): Elevated ALT (greater than 2 times NRH; 3.2%), elevated AST (greater than 2 times NRH; 2.3%), elevated total bilirubin (greater than 1.5 times NRH; 1.9%)

Postmarketing reports: Cholestatic jaundice, abnormal liver function tests


Uncommon (0.1% to 1%): Elevated serum creatinine (greater than 1.5 times NRH; 0.2%)

Frequency not reported: Acute renal failure


Postmarketing reports: Palpitations


Postmarketing reports: Confusion (including delirium, disorientation, and confusional state occurring predominantly in the elderly), hallucinations


Frequency not reported: Upper respiratory tract infection, pharyngitis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Famciclovir