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Exparel

Generic Name: bupivacaine liposome (bue PIV a kane LYE poe some)
Brand Names: Exparel
Exparel (bupivacaine liposome) is used as a local anesthetic in minor surgeries such as bunion removal or hemorrhoid procedures. Includes Exparel side effects, interactions and indications.
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Drug Information:
Exparel (bupivacaine) is an anesthetic (numbing medicine) that blocks nerve impulses in your body. Exparel is used as a local (in only one area) anesthetic to numb an area of your body for a minor surgery such as bunion removal or hemorrhoid surgery. Exparel is also used as a nerve block after surgery on your shoulder or upper arm, to provide pain relief to the area. You may still feel numb or be unable to move the numbed area for up to 5 days after you are treated with Exparel. Before receiving Exparel, tell your doctor if you have liver disease, heart disease, a heart rhythm disorder, or a history of seizures. Learn more

Exparel Side Effects

Exparel Side Effects

Note: This document contains side effect information about bupivacaine liposome. Some of the dosage forms listed on this page may not apply to the brand name Exparel.

For the Consumer

Applies to bupivacaine liposome: injection suspension

Along with its needed effects, bupivacaine liposome (the active ingredient contained in Exparel) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking bupivacaine liposome:

More common

  • Blurred vision
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • sweating

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • collection of blood under the skin
  • decrease in frequency of urination
  • decrease in urine volume
  • deep, dark purple bruise
  • difficulty in passing urine (dribbling)
  • dry mouth
  • headache
  • increased thirst
  • irregular heartbeat
  • itching, pain, redness, or swelling
  • loss of appetite
  • mood changes
  • muscle pain, cramp, or twitching
  • nausea
  • nervousness
  • painful urination
  • pale skin
  • pounding in the ears
  • rapid weight gain
  • seizures
  • slow or fast heartbeat
  • tingling of the hands or feet
  • trouble breathing
  • trouble breathing with exertion
  • unusual bleeding or bruising
  • unusual weight gain or loss
  • vomiting

Incidence not known

  • Chest pain or discomfort
  • loss of consciousness
  • no blood pressure or pulse
  • stopping of the heart
  • weakness of the muscles in your face

Some side effects of bupivacaine liposome may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Motor dysfunction
  • trouble sleeping

Less common

  • Anxiety
  • belching
  • change in taste
  • constipation
  • decreased appetite
  • feeling hot
  • heartburn
  • hiccups
  • indigestion
  • itching in the genitals or other skin areas
  • loss of taste
  • scaling
  • sensory loss
  • stomach discomfort, upset, or pain
  • swelling at the surgical site

Rare

  • Increased sweating

For Healthcare Professionals

Applies to bupivacaine liposome: injectable suspension

General

The most common adverse reactions reported when administration was via infiltration were nausea, vomiting, and dizziness; when administration was via nerve block, common adverse reactions have included nausea, pyrexia, and constipation.

Nervous system

Convulsions have been reported following accidental intravascular injection of this drug and other amide-containing products.

Very common (10% or more): Dizziness (up to 11.3%), motor dysfunction (14.9%)

Common (1% to 10%): Headache, somnolence, hypoesthesia, syncope, dysgeusia, sensory loss

Frequency not reported: Tremor, dizziness postural, paresthesia, syncope, tinnitus, sedation, somnolence, convulsions

Gastrointestinal

Very common (10% or more): Nausea (up to 40.2%), vomiting (up to 27.8%), constipation (up to 22%)

Common (1% to 10%): Anal hemorrhage, painful defecation, rectal discharge, hypoesthesia oral

Frequency not reported: Procedural nausea

Dermatologic

Very common (10% or more): Pruritus (up to 15%)

Common (1% to 10%): Pruritus generalized, hyperhidrosis,

Frequency not reported: Erythema, rash pruritic, cold sweat, urticaria, cellulitis, wound dehiscence, wound secretion, blister, drug eruption, erythema, rash, hematoma

Psychiatric

Common (1% to 10%): Insomnia, confusional state

Frequency not reported: Anxiety, depression, agitation, restlessness

Cardiovascular

Common (1% to 10%): Hypotension, tachycardia, sinus tachycardia, bradycardia, peripheral edema, hypertension

Frequency not reported: Bradycardia, procedural hypertension, procedural hypotension, palpitations, sinus bradycardia, supraventricular extrasystoles, ventricular extrasystoles, ventricular tachycardia, blood pressure increased, blood pressure decreased, pallor, arrhythmia, atrial fibrillation, atrioventricular block first degree, bundle branch block left, bundle branch block right, cardiac arrest, deep vein thrombosis, orthostatic hypotension, electrocardiogram QT prolonged, presyncope, syncope

Cardiac arrest has been reported following accidental intravascular injection of this drug and other amide-containing products.

Hypersensitivity

Rare (less than 0.1%): Allergic-type reactions

Other

Very common (10% or more): Pyrexia (up to 23.3%)

Common (1% to 10%): Procedural pain, lethargy, body temperature increased, feeling hot, post-procedural swelling, fatigue, fall

Frequency not reported: Chills, pain, edema, hearing impaired, asthenia

Hematologic

Common (1% to 10%): Anemia, anemia postoperative, hemorrhagic anemia, postprocedural hematoma

Frequency not reported: White blood cell count increased

Hepatic

Common (1% to 10%): Alanine aminotransferase increased, aspartate aminotransferase increased, increased hepatic enzyme

Musculoskeletal

Common (1% to 10%): Muscle spasms, back pain, muscle twitching

Frequency not reported: Muscular weakness, neck pain, arthralgia, back pain, joint swelling, mobility decreased, muscle spasms, muscular weakness, musculoskeletal pain

Immunologic

Common (1% to 10%): Fungal infection

Metabolic

Common (1% to 10%): Appetite decreased

Frequency not reported: Oxygen saturation decreased, hypokalemia

Renal

Common (1% to 10%): Blood creatinine increased

Respiratory

Common (1% to 10%): Hiccups, hypoxia

Frequency not reported: Laryngospasm, apnea, respiratory depression, respiratory failure, lung infection, pneumonia, cough, dyspnea, lung infiltration, atelectasis

Genitourinary

Frequency not reported: Urinary retention, urinary incontinence, dysuria

Local

Frequency not reported: Incision site edema

Ocular

Frequency not reported: Vision blurred, visual impairment

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Exparel