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Generic Name: cevimeline (se vi ME leen)
Brand Name: Evoxac
Physician reviewed Evoxac patient information - includes Evoxac description, dosage and directions.
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Drug Information:
Evoxac increases the secretions of the saliva and sweat glands in the body. Evoxac is used to treat dry mouth in people with Sjögren's Syndrome. Evoxac may also be used for purposes not listed in this medication guide. You should not take Evoxac if you have uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis. You should not take Evoxac if you are allergic to it, or if you have: untreated or uncontrolled asthma; narrow-angle glaucoma; or an eye condition called iritis or uveitis. Learn more

Evoxac Side Effects

Evoxac Side Effects

Note: This document contains side effect information about cevimeline. Some of the dosage forms listed on this page may not apply to the brand name Evoxac.

In Summary

Common side effects of Evoxac include: rhinitis and diaphoresis. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to cevimeline: oral capsule

Along with its needed effects, cevimeline (the active ingredient contained in Evoxac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cevimeline:

Less common

  • Difficulty breathing
  • fast heartbeat
  • itching


  • Chest pain
  • fainting or light-headedness when getting up from a lying or a sitting position
  • swelling of gums or tongue

Symptoms of Overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking cevimeline:

  • Blurring or loss of vision
  • chest pain
  • cold, clammy skin
  • diarrhea, continuous and severe
  • disturbed color vision
  • dizziness, faintness, or light-headedness when getting up from a lying or sitting position
  • difficult or labored breathing
  • fast, pounding, slow, or irregular heartbeat
  • fast, weak pulse
  • headache
  • mental confusion
  • nausea
  • pounding in ears
  • shaking or trembling of hands or feet
  • shortness of breath
  • stomach cramps or pain
  • sweating
  • tearing of the eyes

Check with your doctor as soon as possible if any of the following side effects occur while taking cevimeline:

Less common

  • Bloody or cloudy urine
  • blurred vision
  • chest pain
  • cough
  • cracks in skin
  • difficult, burning , or painful urination
  • dizziness
  • dry or itching eyes
  • earache
  • feeling of constant movement of self or surroundings
  • itching of vagina, genital, or other skin area
  • lower back pain
  • redness or pain in eye
  • ringing or buzzing in the ears
  • scaling of skin
  • shortness of breath
  • skin rash
  • soreness or redness of skin
  • sores, ulcers, or white spots on tongue, lips, or inside of mouth
  • stiffness of muscles
  • swelling of hands, ankles, feet, or lower legs
  • swelling on side of face and jaw, with or without pain
  • tense muscles

Some side effects of cevimeline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Excessive sweating
  • nausea
  • runny or stuffy nose

Less common

  • Abdominal pain
  • belching
  • bloating or swelling of face, hands, feet, or lower legs
  • bloody nose
  • bone or joint pain
  • burning, dry, or itching feeling in eye
  • change in vision
  • chills
  • constipation
  • cough, mucus-producing
  • decreased touch sensation
  • depression
  • diarrhea
  • dry mouth
  • eye pain
  • feelings of warmth in face, neck, arms, and occasionally, chest
  • fever
  • heartburn
  • hiccups
  • injury
  • itching
  • leg cramps
  • loss of appetite
  • migraine headache
  • mood or mental changes
  • muscle aches, pain, or stiffness
  • pain and swelling of eye, eyelid, or inner lining of eye
  • pain on side of face and jaw
  • pain, swelling, or redness of joints
  • postoperative pain
  • rapid weight gain
  • shortness of breath
  • skin disorder
  • tightness in chest
  • tooth disorders or pain
  • trembling or shaking of hands or feet
  • trouble in sleeping
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • watering of mouth
  • weight loss


  • Abnormal crying
  • deep, dark, purple bruise
  • swelling or puffiness of face
  • temperature sensation changes

For Healthcare Professionals

Applies to cevimeline: oral capsule


The most commonly reported side effects were excessive sweating, nausea, diarrhea, rhinitis, sinusitis, upper respiratory tract infection, and headache.


Common (1% to 10%): Hot flushes

Uncommon (0.1% to 1%): Flushing, precordial chest pain, hematoma, pallor, substernal chest pain, abnormal ECG, heart disorder, heart murmur, aggravated hypertension, hypotension, arrhythmia, extrasystoles, t wave inversion, tachycardia, supraventricular tachycardia, angina pectoris, myocardial infarction, pericarditis, peripheral ischemia, superficial phlebitis, purpura, deep thrombophlebitis, vasculitis, vascular disorder, hypertension, post-operative hemorrhage

Frequency not reported: Blood pressure fluctuation, cardiomegaly, postural hypotension, bundle branch block, distended vein


Uncommon (0.1% to 1%): Cholelithiasis, increased gamma-glutamyl transferase, increased hepatic enzymes, abnormal hepatic function, viral hepatitis, increased serum glutamate oxaloacetic transaminase (SGOT/AST), increased serum glutamate pyruvate transaminase (SGPT/ALT) Postmarketing reports: Cholecystitis


Uncommon (0.1% to 1%): Cholelithiasis, increased gamma-glutamyl transferase, increased hepatic enzymes, abnormal hepatic function, viral hepatitis, increased serum glutamate oxaloacetic transaminase (SGOT/AST), increased serum glutamate pyruvate transaminase (SGPT/ALT) Postmarketing reports: Cholecystitis


Very common (10% or more): Nausea (13.8%), Diarrhea (10.3%)

Common (1% to 10%): Excessive salivation, dyspepsia, abdominal pain, vomiting

Uncommon (0.1% to 1%): Mouth edema, appendicitis, ulcerative colitis, diverticulitis, duodenitis, dysphagia, enterocolitis, gastric ulcer, gastritis, gastroenteritis, gastrointestinal hemorrhage, gingivitis, glossitis, rectum hemorrhage, hemorrhoids, ileus, irritable bowel syndrome, melena, mucositis, esophageal stricture, esophagitis, oral hemorrhage, peptic ulcer, periodontal destruction, rectal disorder, stomatitis, tenesmus, tongue discoloration, tongue disorder, geographic tongue, tongue ulceration, dental caries, food poisoning

Frequency not reported: Enlarged abdomen, change in bowel habits, gum hyperplasia, intestinal obstruction

Nervous system

Very common (10% or more): Headache (14.4%)

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Syncope, carpal tunnel syndrome, coma, abnormal coordination, dysesthesia, dyskinesia, dysphonia, aggravated multiple sclerosis, involuntary muscle contractions, neuralgia, neuropathy, paresthesia, speech disorder, agitation, confusion, depersonalization, aggravated depression, abnormal dreaming, emotional lability, manic reaction, paroniria, somnolence, abnormal thinking, hyperkinesia, hallucination, motion sickness, parosmia, taste perversion

Frequency not reported: Cholinergic syndrome, aphasia, convulsions, abnormal gait, hyperesthesia, paralysis, amnesia, neurosis


Very common (10% or more): Sinusitis (12.3%), upper respiratory tract infection (11.4%), rhinitis (11.2%)

Common (1% to 10%): Coughing, pharyngitis, bronchitis

Uncommon (0.1% to 1%): Choking, pulmonary embolism, asthma, bronchospasm, chronic obstructive airway disease, dyspnea, hemoptysis, laryngitis, nasal ulcer, pleural effusion, pleurisy, pulmonary congestion, pulmonary fibrosis, respiratory disorder

Frequency not reported: Apnea, atelectasis, yawning


Uncommon (0.1% to 1%): Genital moniliasis, epididymitis, prostatic disorder, abnormal sexual function, amenorrhea, female breast neoplasm, malignant female breast neoplasm, female breast pain, positive cervical smear test, dysmenorrhea, endometrial disorder, intermenstrual bleeding, leukorrhea, menorrhagia, menstrual disorder, ovarian cyst, ovarian disorder, genital pruritus, uterine hemorrhage, vaginal hemorrhage, atrophic vaginitis, albuminuria, bladder discomfort, increased blood urea nitrogen, dysuria, hematuria, micturition disorder, nephrosis, nocturia, increased nonprotein nitrogen, pyelonephritis, renal calculus, abnormal renal function, renal pain, strangury, urethral disorder, abnormal urine, urinary incontinence, decreased urine flow, pyuria

Frequency not reported: Abnormal sexual function, impotence, oliguria, urinary retention


Common (1% to 10%): Back pain, arthralgia, skeletal pain

Uncommon (0.1% to 1%): Leg pain, arthritis, aggravated arthritis, arthropathy, femoral head avascular necrosis, bone disorder, bursitis, costochondritis, plantar fasciitis, muscle weakness, osteomyelitis, osteoporosis, synovitis, tendinitis, tenosynovitis, joint dislocation, aggravated rheumatoid arthritis


Very common (10% or more): Excessive sweating (18.7%)

Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Cellulitis, lupus erythematosus rash, lupus erythematosus syndrome, acne, alopecia, burn, dermatitis, contact dermatitis, lichenoid dermatitis, eczema, furunculosis, hyperkeratosis, lichen planus, nail discoloration, nail disorder, onychia, onychomycosis, paronychia, photosensitivity reaction, rosacea, scleroderma, seborrhea, skin discoloration, dry skin, skin exfoliation, skin hypertrophy, skin ulceration, urticaria, verruca, bullous eruption, cold clammy skin


Common (1% to 10%): Conjunctivitis, rigors

Uncommon (0.1% to 1%): Periorbital edema, blepharitis, cataract, corneal opacity, corneal ulceration, diplopia, glaucoma, anterior chamber eye hemorrhage, keratitis, keratoconjunctivitis, mydriasis, myopia, photopsia, retinal deposits, retinal disorder, scleritis, vitreous detachment


Uncommon (0.1% to 1%): Increased glucocorticoids, goiter, hypothyroidism


Uncommon (0.1% to 1%): Aggravated allergy, herpes simplex, herpes zoster, bacterial infection, viral infection, sepsis


Uncommon (0.1% to 1%): Weight decrease, weight increase, increased appetite, dehydration, diabetes mellitus, hypercalcemia, hypercholesterolemia, hyperglycemia, hyperlipemia, hypertriglyceridemia, hyperuricemia, hypoglycemia, hypokalemia, hyponatremia, thirst

Frequency not reported: Electrolyte abnormality, hyperkalemia, hyperproteinemia, failure to thrive, gout


Uncommon (0.1% to 1%): Basal cell carcinoma, squamous carcinoma


Common (1% to 10%): Injury, surgical intervention, fatigue, pain

Uncommon (0.1% to 1%): Asthenia, abnormal crying, edema, activated pain trauma, changed temperature sensation, malaise, face edema, fall, heat stroke, deafness, decreased hearing, tinnitus

Frequency not reported: Increased creatine phosphokinase, increased lactic dehydrogenase (LDH), increased alkaline phosphatase


Common (1% to 10%): Insomnia, anxiety

Frequency not reported: Aggressive reaction, apathy, delirium, delusion, dementia, illusion, paranoid reaction, personality disorder


Common (1% to 10%): Urinary tract infection

Uncommon (0.1% to 1%): Urinary frequency, polyuria, glycosuria

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Evoxac