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Generic Name: asparaginase Erwinia chrysanthemi (as PAR a jin ase er WIN ee a kri SAN the mee)
Brand Names: Erwinaze
Erwinaze (asparaginase Erwinia chrysanthemi) is used to treat acute lymphoblastic leukemia. Includes Erwinaze side effects, interactions and indications.
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Drug Information:
Erwinaze is an injectable medicine containing asparaginase Erwinia chrysanthemi. Asparaginase is a cancer medication that interferes with the growth and spread of cancer cells in the body. Erwinaze is used to treat acute lymphocytic lymphoma. Erwinaze may also be used for other purposes not listed in this medication guide. You should not receive Erwinaze if you are allergic to asparaginase Erwinia chrysanthemi, or if you have received asparaginase (Elspar) in the past and it caused you to have serious pancreas problems, a blood clot, or serious bleeding problems. Learn more

Erwinaze Side Effects

Erwinaze Side Effects

Note: This document contains side effect information about asparaginase erwinia chrysanthemi. Some of the dosage forms listed on this page may not apply to the brand name Erwinaze.

In Summary

Common side effects of Erwinaze include: anaphylaxis. Other side effects include: pancreatitis and severe hypersensitivity reaction. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to asparaginase erwinia chrysanthemi: injection powder for solution

Along with its needed effects, asparaginase erwinia chrysanthemi (the active ingredient contained in Erwinaze) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking asparaginase erwinia chrysanthemi:

More common

  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • fever
  • hives or welts, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness

Less common

  • Abdominal or stomach pain
  • bloating
  • blurred vision
  • chills
  • constipation
  • dark urine
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • increased hunger
  • increased thirst
  • increased urination
  • indigestion
  • loss of appetite
  • nausea
  • pains in the chest, groin, or legs, especially calves of the legs
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • seizures
  • severe headaches of sudden onset
  • sudden loss of coordination
  • sudden onset of slurred speech
  • sudden vision changes
  • sweating
  • unexplained weight loss
  • vomiting
  • yellow eyes or skin


  • Blood in the urine or stools
  • bruising
  • confusion
  • coughing or vomiting blood
  • headache
  • numbness or tingling in the face, arms, or legs
  • persistent bleeding or oozing from puncture sites, mouth, or nose
  • red streaks on the skin
  • swelling, tenderness, or pain at the injection site
  • trouble speaking, thinking, or walking

Some side effects of asparaginase erwinia chrysanthemi may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Diarrhea

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: injectable powder for injection


Most common adverse reactions were systemic hypersensitivity, hyperglycemia, abnormal transaminases, fever, pancreatitis, local reactions, vomiting, nausea, thrombosis, hyperbilirubinemia, abdominal pain/discomfort, and diarrhea.


Very common (10% or more): Systemic hypersensitivity (14%)

Very rare (less than 0.01%): Anaphylaxis


Common (1% to 10%): Pancreatitis, vomiting, nausea, abdominal pain/discomfort, diarrhea, serum amylases increased, serum lipase increased

Nervous system

Common (1% to 10%): Lethargy, somnolence, confusion, dizziness, neurotoxicity, convulsions, headache

Rare (less than 0.1%): Dysphasia, dysphagia, CNS depression, coma


Common (1% to 10%): Rash, urticarial, pruritus, erythema, facial edema


Common (1% to 10%): Transaminases abnormal, hyperbilirubinemia, alkaline phosphatase increased, cholesterol increased

Rare (less than 0.1%): Hepatic failure

Frequency not reported: Hepatomegaly, cholestatic jaundice


Common (1% to 10%): Hypofibrinogenemia, asymptomatic coagulopathy

Very rare (less than 0.01%): Neutropenia, febrile neutropenia, thrombocytopenia

Frequency not reported: clotting factor decreased, antithrombin III decreased, protein C decreased, protein S decreased, fibrinogen decreased


Common (1% to 10%): Thrombosis, pallor

Very rare (less than 0.01%): Hemorrhage

Frequency not reported: Hypertension


Common (1% to 10%): Hyperglycemia

Uncommon (0.1% to 1%): Hyperlipidemia

Rare (0.01% to 0.1%): Diabetic ketoacidosis

Very rare (less than 0.01%): Hyperammonemia


Common (1% to 10%): Local reactions


Common (1% to 10%): Fever


Very rare (less than 0.01%): Myalgia, reactive arthritis

Frequency not reported: Extremity pain


Very rare (less than 0.01%): Life-threatening sepsis

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Erwinaze