Note: This document contains side effect information about epinephrine. Some of the dosage forms listed on this page may not apply to the brand name EpiPen 2-Pak.
Applies to epinephrine: injection solution
Along with its needed effects, epinephrine (the active ingredient contained in EpiPen 2-Pak) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking epinephrine:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking epinephrine:
Symptoms of overdose
Applies to epinephrine: compounding powder, inhalation aerosol, inhalation solution, injectable kit, injectable solution, intravenous solution, subcutaneous suspension
Due to the lack of randomized, controlled clinical trials for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of this drug is difficult to determine. The most commonly reported adverse reactions include anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, nausea and vomiting, headache, and/or respiratory difficulties.
Frequency not reported: Tachycardia, supraventricular tachycardia, ventricular arrhythmias, myocardial ischemia, myocardial infarction, limb/peripheral ischemia, palpitations, angina, arrhythmias, hypertension, vasoconstriction, ventricular ectopy, ventricular fibrillation, cold extremities, electrocardiogram changes, stress cardiomyopathy
Frequency not reported: Headache, paresthesia, tremor, stroke, central nervous system bleeding, dizziness, cerebral hemorrhage, memory impaired, lightheadedness, psychomotor agitation, tingling, Parkinsonism aggravated, syncope, convulsions, subarachnoid hemorrhage, hemiplegia
Frequency not reported: Nervousness, excitability, anxiety, apprehension, restlessness, disorientation, panic, hallucinations, psychosis, fear, sleeplessness/insomnia, tenseness, confusion, irritability
Frequency not reported: Extravasation, injection site pallor, coldness at injection site, hypoesthesia at injection site, injury at injection site, local ischemic necrosis
Frequency not reported: Diaphoresis, pallor, piloerection, skin blanching, skin necrosis with extravasation, necrotizing fasciitis, flushing/redness of skin and face, hyperhidrosis
Frequency not reported: Hypoglycemia, hyperglycemia, insulin resistance, hypokalemia, lactic acidosis, insulin secretion inhibited, metabolic acidosis, anorexia
Frequency not reported: Pulmonary edema, rales, respiratory difficulty, dyspnea, bronchospasm, hypoxia of mucosa
Frequency not reported: Renal insufficiency
Hypersensitivity side effects have been extremely unusual. Contact dermatitis has been associated with ocularly applied epinephrine (the active ingredient contained in EpiPen 2-Pak) These reactions have typically presented with lid edema and a thick yellow discharge.
Frequency not reported: Nausea, vomiting, bowel necrosis, hypersalivation
Frequency not reported: Urinary retention, difficult micturition
Frequency not reported: Thrombocytosis
Frequency not reported: Myonecrosis
Frequency not reported: Chest pain, weakness, gas gangrene, asthenia
Frequency not reported: Corneal endothelial damage
Frequency not reported: Growth hormone secretion stimulated
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Epipen 2-pak