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Generic Name: sacubitril and valsartan (sak UE bi tril and val SAR tan)
Brand Names: Entresto
Entresto (sacubitril/valsartan) is used to reduce risk of death and hospitalization in heart failure patients. Includes Entresto side effects, interactions and indications.
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Drug Information:
Entresto contains a combination of sacubitril and valsartan. Sacubitril is a blood pressure medicine. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. This helps lower blood pressure by reducing sodium levels. Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Entresto is used in certain people with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure. Learn more

Entresto Side Effects

Entresto Side Effects

Note: This document contains side effect information about sacubitril / valsartan. Some of the dosage forms listed on this page may not apply to the brand name Entresto.

In Summary

Common side effects of Entresto include: hyperkalemia, hypotension, and increased serum creatinine. Other side effects include: acute renal failure, and renal failure syndrome. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to sacubitril / valsartan: oral tablet


Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system may cause fetal injury or death. Discontinue use immediately if pregnancy is detected.

Along with its needed effects, sacubitril/valsartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sacubitril / valsartan:

More common

  • Abdominal or stomach pain
  • blurred vision
  • confusion
  • difficult breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • irregular heartbeat
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • sweating
  • unusual tiredness or weakness
  • weakness or heaviness of the legs

Less common

  • Bloody urine
  • decreased frequency or amount of urine
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • swelling of the face, fingers, or lower legs
  • weight gain


  • Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

Some side effects of sacubitril / valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Cough
  • dizziness

For Healthcare Professionals

Applies to sacubitril / valsartan: oral tablet


The most common adverse reactions were hypotension, hyperkalemia, cough, dizziness, and renal failure.


Very common (10% or more): Hypotension (18%)

Common (1% to 10%): Orthostasis


Very common (10% or more): Potassium greater than 5.5 mEq/L (16%), hyperkalemia (12%)


Very common (10% or more): Serum creatinine increased greater than 50% (16%)

Common (1% to 10%): Renal failure/acute renal failure


Common (1% to 10%): Cough

Nervous system

Common (1% to 10%): Dizziness


Uncommon (0.1% to 1%): Angioedema

Postmarketing reports: Rash, pruritus

The incidence of angioedema was 2.4% in Black patients.


Common (1% to 10%): Hemoglobin/hematocrit decreased greater than 20%


Common (1% to 10%): Falls


Postmarketing reports: Hypersensitivity, anaphylactic reaction

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Entresto