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Generic Name: alvimopan (AL vi MOE pan)
Brand Names: Entereg
Entereg (alvimopan) is used to speed recovery of stomach and intestinal functions after a gastrointestinal surgery. Includes Entereg side effects, interactions and indications.
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Drug Information:
Entereg (alvimopan) reduces certain side effects of narcotic medicines that are often used to prevent pain caused by surgery. Narcotic medicine can cause stomach pain, bloating, nausea, vomiting, and constipation. These side effects can delay recovery in patients undergoing gastrointestinal surgery. Entereg helps prevent these side effects without reducing the pain-relieving effects of the narcotic. Entereg is used to help restore normal digestive functioning after surgery to remove a portion of your intestine. This medicine is available only under a special program for short-term use (no more than 15 doses). You must be registered in the program and understand the risks and benefits of taking this medicine. Learn more

Entereg Side Effects

Entereg Side Effects

Note: This document contains side effect information about alvimopan. Some of the dosage forms listed on this page may not apply to the brand name Entereg.

In Summary

More frequent side effects include: constipation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to alvimopan: oral capsule


Oral route (Capsule)

Increased incidence of myocardial infarction was seen in alvimopan-treated patients compared with placebo-treated patients in a 12-month clinical trial. Alvimopan is available only for short-term (15 doses) use through a restricted program called the ENTEREG® Access Support and Education (E.A.S.E.®) Program.

Along with its needed effects, alvimopan (the active ingredient contained in Entereg) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking alvimopan:

More common

  • Acid or sour stomach
  • belching
  • bloated
  • convulsions
  • decreased urine
  • difficulty having a bowel movement (stool)
  • dry mouth
  • excess air or gas in stomach or intestines
  • full feeling
  • heartburn
  • increased thirst
  • indigestion
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea or vomiting
  • numbness or tingling in hands, feet, or lips
  • pale skin
  • passing gas
  • shortness of breath
  • stomach discomfort, upset, or pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Decrease in frequency of urination
  • decrease in urine volume
  • difficulty in passing urine (dribbling)
  • painful urination

Some side effects of alvimopan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain

For Healthcare Professionals

Applies to alvimopan: oral capsule


Hematologic side effects including anemia (5.2% to 5.4%).


Genitourinary side effects have included urinary retention (3.2% to 3.5%).


Gastrointestinal side effects have included constipation (4% to 9.7%), flatulence (3.1% to 8.7%), and dyspepsia (5.9% to 7%).


Metabolic side effects have included hypokalemia (6.9% to 9.5%).


Musculoskeletal side effects have included back pain (3.3% to 3.4%).

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Entereg