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Generic Name: elotuzumab (EL oh TOOZ ue mab)
Brand Names: Empliciti
Empliciti (elotuzumab) is used to treat multiple myeloma. Includes Empliciti side effects, interactions and indications.
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Drug Information:
Empliciti (elotuzumab) is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Empliciti is used in combination chemotherapy to treat multiple myeloma (bone marrow cancer). Empliciti is given together with either lenalidomide or pomalidomide, and a steroid medicine called dexamethasone. Lenalidomide (Revlimid) is available only under a special program. You must be registered in the program and understand the risks and benefits of taking this medicine. Learn more

Empliciti Side Effects

Empliciti Side Effects

Note: This document contains side effect information about elotuzumab. Some of the dosage forms listed on this page may not apply to the brand name Empliciti.

In Summary

More frequent side effects include: fever. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to elotuzumab: intravenous powder for solution

Along with its needed effects, elotuzumab (the active ingredient contained in Empliciti) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking elotuzumab:

More common

  • Blurred vision
  • body aches or pain
  • chest pain
  • chills
  • confusion
  • cough or hoarseness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • ear congestion
  • facial swelling
  • fever or chills
  • headache
  • hives, itching, or rash
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • nausea or vomiting
  • nervousness
  • painful or difficult urination
  • pounding in the ears
  • redness of the skin
  • runny nose
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • sweating
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness

Less common

  • Abdominal pain or tenderness
  • clay-colored stools
  • dark urine
  • loss of appetite
  • persistent sore that does not heal
  • pink skin growth
  • reddish patch or irritated area
  • shiny skin bump
  • swelling of the feet or lower legs
  • white, yellow or waxy scar-like area on the skin
  • yellow eyes or skin

Some side effects of elotuzumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Blindness
  • burning, numbness, tingling, or painful sensations
  • decreased appetite
  • decreased vision
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement (stool)
  • muscle aches
  • night sweats
  • pain in the arms or legs
  • unsteadiness or awkwardness
  • weakness in the arms, hands, legs, or feet

For Healthcare Professionals

Applies to elotuzumab: intravenous powder for injection


Common (1% to 10%): Night sweats


Very common (10% or more): Diarrhea (47%), constipation (36%), vomiting (15%), oropharyngeal pain (10%)


Very common (10% or more): Lymphopenia (13%)

Frequency not reported: Leukopenia, thrombocytopenia, deep vein thrombosis


Frequency not reported: Hypoalbuminemia, elevated alkaline phosphatase


Common (1% to 10%): Hypersensitivity

Uncommon (0.1% to 1%): Anaphylactic reaction


Very common (10% or more): Decreased appetite (21%), weight loss (14%)

Frequency not reported: Hyperglycemia, hypocalcemia, low bicarbonate, hyperkalemia


Very common (10% or more): Pain in extremities (16%)

Common (1% to 10%): Chest pain

Nervous system

Very common (10% or more): Peripheral neuropathy (27%), headache (15%)

Common (1% to 10%): Hypoesthesia


Very common (10% or more): Cataracts (12%)


Common (1% to 10%): Invasive second primary malignancies (SPM)


Very common (10% or more): Fatigue (62%), pyrexia (37%)


Common (1% to 10%): Altered mood


Common (1% to 10%): Acute renal failure


Very common (10% or more): Cough (34%), nasopharyngitis (25%), upper respiratory tract infection (23%), pneumonia (20%)

Common (1% to 10%): Respiratory tract infection, pulmonary embolism


Very common (10% or more): Herpes zoster


Common (1% to 10%): Infusion related reaction

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Empliciti