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Generic Name: apixaban (a PIX a ban)
Brand Names: Eliquis
Eliquis (apixaban) is used to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. Includes Eliquis side effects, interactions and indications.
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Drug Information:
Eliquis (apixaban) blocks the activity of certain clotting substances in the blood. Eliquis is used to lower the risk of stroke or a blood clot in people with a heart rhythm disorder called atrial fibrillation. Eliquis is also used to lower the risk of forming a blood clot in the legs and lungs of people who have just had hip or knee replacement surgery. Eliquis is used to treat blood clots in the veins of your legs (deep vein thrombosis) or lungs (pulmonary embolism), and lower the risk of them occurring again. Learn more

Eliquis Side Effects

Eliquis Side Effects

Note: This document contains side effect information about apixaban. Some of the dosage forms listed on this page may not apply to the brand name Eliquis.

For the Consumer

Applies to apixaban: oral tablet


Oral route (Tablet)

Premature discontinuation of apixaban or any oral anticoagulant increases the risk of thrombotic events. Consider an alternative anticoagulant if apixaban treatment is discontinued for any reason other than pathological bleeding or treatment completion. In patients undergoing neuraxial anesthesia or spinal puncture, epidural or spinal hematoma risk is increased and could result in long-term or permanent paralysis. The optimal timing between dosing apixaban and neuraxial procedures is unknown. Monitor patients for signs and symptoms of neurologic impairment and treat urgently. Consider the benefits and risks of neuraxial intervention in patients who are or need to be anticoagulated.

Along with its needed effects, apixaban (the active ingredient contained in Eliquis) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking apixaban:


  • Blood in the eyes
  • blood in the urine
  • bloody or black, tarry stools
  • bruising or purple areas on the skin
  • confusion
  • constipation
  • coughing up blood
  • decreased alertness
  • difficulty swallowing
  • dizziness
  • fainting
  • fast heartbeat
  • headache
  • hives, itching, skin rash
  • joint pain or swelling
  • nausea and vomiting
  • nosebleeds
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the eye
  • severe stomach pain
  • shortness of breath
  • tightness in the chest
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

For Healthcare Professionals

Applies to apixaban: oral tablet


The most common adverse events were related to bleeding. Common adverse reactions were anemia, hemorrhage, and nausea.


Very common (10% or more): Minor bleed (11.7%)

Common (1% to 10%): Anemia postoperative, clinically relevant nonmajor bleed, hemoglobin decreased, anemia, hemorrhage

Uncommon (0.1% to 1%): Postprocedural hemorrhage, hemoglobin decrease of 2 g/dL or more, transfusion of 2 units or more red blood cells, fatal bleed, thrombocytopenia, hemorrhagic anemia

Rare (less than 0.1%): Bleed at critical site

Patients with diabetes had more bleeding events than non-diabetic subjects. Hemorrhage includes hematoma, and vaginal and urethral hemorrhage. Postprocedural hemorrhage includes postprocedural hematoma, wound hemorrhage, vessel puncture site hematoma, and catheter site hemorrhage.


Very common (10% or more): Nausea (14.1%)

Common (1% to 10%): Constipation, vomiting, diarrhea, abdominal pain upper, abdominal pain, dyspepsia, gastritis, gastroenteritis, toothache, gingival bleeding, rectal hemorrhage, dyspepsia, gastrointestinal hemorrhage (including hematemesis and melena),

Uncommon (0.1% to 1%): Major gastrointestinal bleed, hematochezia, hemorrhoidal hemorrhage, hematemesis, melena, anal hemorrhage, occult blood positive, occult blood, intra-abdominal hemorrhage, mouth hemorrhage

Rare (less than 0.1%): Retroperitoneal hemorrhage


Common (1% to 10%): Hypotension, peripheral edema, atrial fibrillation, cardiac failure, hypertension, deep vein thrombosis, tachycardia, cardiac failure congestive, palpitations, thrombosis, angina pectoris, bradycardia, blood pressure increased, procedural hypotension, unstable angina, tachycardia

Nervous system

Common (1% to 10%): Dizziness, headache, fatigue, syncope, ischemic stroke, vertigo

Uncommon (0.1% to 1%): Somnolence, cerebrovascular accident, transient ischemic attack, major intracranial bleed, brain hemorrhage, other intracranial or intraspinal hemorrhage (including subdural hematoma, subarachnoid hemorrhage, and spinal hematoma)

Frequency not reported: Stroke


Common (1% to 10%): Hematoma, wound hemorrhage, wound secretion

Uncommon (0.1% to 1%): Incision-site hemorrhage, operative hemorrhage, traumatic hematoma, injection site hematoma, vessel puncture site hematoma, application site bleeding, traumatic hemorrhage


Common (1% to 10%): Cataract, conjunctival hemorrhage, eye hemorrhage

Uncommon (0.1% to 1%): Major intraocular bleed, periorbital hematoma, conjunctival hemorrhage, retinal hemorrhage

Frequency not reported: Ocular hemorrhage


Common (1% to 10%): Nasopharyngitis, dyspnea, epistaxis, bronchitis, cough, upper respiratory tract infection, influenza, pneumonia, sinusitis, chronic obstructive pulmonary disease, lower respiratory tract infection, hemoptysis, dyspnea exertional, respiratory tract infection

Uncommon (0.1% to 1%): Dyspnea

Rare (less than 0.1%): Pulmonary embolism, respiratory tract hemorrhage (including pulmonary alveolar hemorrhage, laryngeal hemorrhage, and pharyngeal hemorrhage)


Very common (10% or more): Procedural pain (10.3%)

Common (1% to 10%): Pyrexia, chest pain, fall, asthenia, blood creatine phosphokinase increased, pain, body temperature increased, laceration, chest discomfort, tooth extraction

Uncommon (0.1% to 1%): Herpes zoster


Common (1% to 10%): Urinary tract infection, menorrhagia

Uncommon (0.1% to 1%): vaginal hemorrhage, metrorrhagia, menometrorrhagia, genital hemorrhage, blood urine present, red blood cells urine positive, abnormal vaginal hemorrhage, urogenital hemorrhage


Common (1% to 10%): Hematuria, blood creatinine increased, renal failure


Common (1% to 10%): Arthralgia, back pain, pain in extremity, osteoarthritis, muscle spasms, musculoskeletal pain, myalgia, arthritis

Uncommon (0.1% to 1%): Muscle hemorrhage, joint swelling


Common (1% to 10%): Gout, diabetes mellitus, blood glucose increased, hyperglycemia, hypokalemia, decreased appetite


Uncommon (0.1% to 1%): Hypersensitivity (including drug hypersensitivity such as skin rash and anaphylactic reaction such as allergic edema)


Uncommon (0.1% to 1%): Transaminases increased, AST increased, ALT increased, gamma-glutamyl transferase increased, liver function test abnormal, blood alkaline phosphatase increased, blood bilirubin increased


Common (1% to 10%): Insomnia, depression

Uncommon (0.1% to 1%): Anxiety


Common (1% to 10%): Pruritus, contusion, rash, cellulitis, ecchymosis, erythema, blister

Uncommon (0.1% to 1%): Skin hemorrhage, petechiae, skin rash


Uncommon (0.1% to 1%): Basal cell carcinoma

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Eliquis