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Generic Name: epinastine ophthalmic (EP i NAS teen off THAL mik)
Brand Names: Elestat
Elestat (epinastine) is used to prevent itching of the eyes associated with allergies. Includes Elestat side effects, interactions and indications.
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Drug Information:
Elestat eye drops contain epinastine, an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Elestat is used to prevent itching of the eyes caused by allergies. Elestat should not be used to treat eye irritation or discomfort caused by wearing contact lenses. Elestat may also be used for purposes not listed in this medication guide. Elestat is usually used only for a short time until allergy season ends. Learn more

Elestat Side Effects

Elestat Side Effects

Note: This document contains side effect information about epinastine ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Elestat.

For the Consumer

Applies to epinastine ophthalmic: ophthalmic solution

Along with its needed effects, epinastine ophthalmic (the active ingredient contained in Elestat) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking epinastine ophthalmic:

More common

  • Burning sensation in the eye
  • increase in blood flow to the whites of the eyes
  • redness, itching, pain, swelling, or other irritation of the eye

Some side effects of epinastine ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

- some side effects were similar to problem being treated
  • Body aches or pain
  • chills
  • cough
  • difficulty with breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • sore throat
  • unusual tiredness or weakness

Less common

- some side effects were similar to problem being treated
  • Congestion
  • hoarseness
  • increased cough
  • pain or tenderness around the eyes and cheekbones
  • shortness of breath
  • stuffy nose
  • tender, swollen glands in the neck
  • tightness of the chest or wheezing
  • trouble with swallowing
  • troubled breathing
  • voice changes

For Healthcare Professionals

Applies to epinastine ophthalmic: ophthalmic solution


The most common ocular side effects reported were a burning sensation following instillation, folliculosis, hyperemia, and pruritus of the eye.


Common: Burning, irritation, pruritus

Uncommon: Hyperemia, discharge, dryness, visual disturbance

Postmarketing reports: Increased lacrimation, eye pain


Uncommon: Asthma, nasal irritation, rhinitis

Nervous system

Uncommon: Headache, dysgeusia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Elestat