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Generic Name: taliglucerase alfa (TAL i GLOO ser ase AL fa)
Brand Names: Elelyso
Elelyso (taliglucerase alfa) is used to treat Gaucher disease. Includes Elelyso side effects, interactions and indications.
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Drug Information:
Elelyso (taliglucerase) is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in adults and children at least 4 years old with Type I Gaucher disease. Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured. Learn more

Elelyso Side Effects

Elelyso Side Effects

Note: This document contains side effect information about taliglucerase alfa. Some of the dosage forms listed on this page may not apply to the brand name Elelyso.

In Summary

Common side effects of Elelyso include: arthralgia, back pain, and headache. Other side effects include: asthenia, chest discomfort, chest pain, fatigue, increased blood pressure, urticaria, erythema of skin, and flushing. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to taliglucerase alfa: intravenous powder for solution

Along with its needed effects, taliglucerase alfa (the active ingredient contained in Elelyso) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking taliglucerase alfa:

More common

  • Chest tightness
  • dizziness
  • feeling of warmth
  • hives or welts, itching, or skin rash
  • irritation in the throat
  • large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • nausea or vomiting
  • redness of the face, neck, arms, and occasionally, upper chest
  • redness of the skin

Less common

  • Blurred vision
  • confusion
  • cough
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast heartbeat
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sweating
  • unusual tiredness or weakness

Some side effects of taliglucerase alfa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • difficulty with moving
  • feeling of warmth
  • headache
  • muscle pain or stiffness
  • pain in the joints

Incidence not known

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to taliglucerase alfa: intravenous powder for injection


The most frequently reported side effects were headache, arthralgia, pain in extremity, fatigue, nausea, dizziness, pruritus, flushing, abdominal pain, vomiting, back pain, and rash.


Very common (10% or more): Vomiting, abdominal pain

Common (1% to 10%): Nausea, diarrhea

Frequency not reported: Gastrointestinal inflammation


In clinical trials, hypersensitivity reactions (including anaphylaxis) were reported in 29% of patients; these reactions occurred up to 3 hours after the start of infusion. Serious hypersensitivity reactions (including anaphylaxis) were reported in some patients. In clinical trials, 3% of patients had signs/symptoms consistent with anaphylaxis; these reactions occurred during the infusion.

Very common (10% or more): Hypersensitivity reactions (including anaphylaxis; 29%)

Frequency not reported: Type III immune-mediated fixed drug eruption

Postmarketing reports: Anaphylaxis


Very common (10% or more): Arthralgia (up to 13%), pain in extremity (up to 10%)

Common (1% to 10%): Back pain, bone pain

Frequency not reported: Muscle spasms


Very common (10% or more): Development of anti-drug antibodies (up to 53%), neutralizing antibodies detected (10.3%)

Nervous system

Very common (10% or more): Headache (up to 19%)

Common (1% to 10%): Dizziness, paresthesia

Frequency not reported: Tremor


Common (1% to 10%): Fatigue, flushing, peripheral edema, infusion reaction, weight increased

Frequency not reported: Chest discomfort, feeling hot

Infusion-related reactions occurred most often within 24 hours of the infusion and consisted of arthralgia, headache, vomiting, flushing, pruritus, pain in extremity, pulmonary hypertension, diarrhea, chest discomfort, feeling hot, muscle spasms, tremor, throat irritation, erythema, and rash.


Common (1% to 10%): Pruritus, erythema, rash, urticaria


Common (1% to 10%): Throat irritation, rhinorrhea, sneezing

Frequency not reported: Pulmonary hypertension


Common (1%to 10%): ALT increased


Common (1% to 10%): Infusion site pain


Common (1% to 10%): Eye pruritus, eye swelling, lacrimation increased

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Elelyso