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Edetate calcium disodium

Generic Name: edetate calcium disodium (ED e tate KAL see um dye SOE dee um)
Brand Name: Calcium Disodium Versenate
Physician reviewed edetate calcium disodium patient information - includes edetate calcium disodium description, dosage and directions.
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Drug Information:
Edetate calcium disodium is a chelating (KEE-late-ing) agent that can remove a heavy metal from the blood. Edetate calcium disodium is used to treat lead poisoning. Edetate calcium disodium may also be used for purposes not listed in this medication guide. You should not receive edetate calcium disodium if you are unable to urinate, or if you have active hepatitis or kidney disease. Edetate calcium disodium can have toxic effects in the body, which may cause life-threatening medical problems. Call your doctor at once if you have memory problems, mood changes, trouble concentrating, changes in behavior or mental status, or if you feel irritable. Learn more

Edetate calcium disodium Side Effects

Edetate calcium disodium Side Effects

For the Consumer

Applies to edetate calcium disodium: parenteral injection


    Fatality Risk
  • Risk of potentially fatal toxic effects. (See Fatality Risk and also see Renal Effects under Cautions.)

  • Possible lethal increase in intracranial pressure following IV infusion in patients with lead encephalopathy and cerebral edema. Manufacturer recommends IM administration in this patient population. If administered IV, avoid rapid infusion. (See Administration under Dosage and Administration and see Fatality Risk under Cautions.)

  • Follow dosage schedule; do not exceed recommended daily dose.

    Encephalopathy Risk
  • Lead encephalopathy occurs rarely in adults; occurs more often in pediatric patients, in whom encephalopathy may be incipient and overlooked and results in high mortality rate.

Side effects include:

Injection site pain.

For Healthcare Professionals

Applies to edetate calcium disodium: compounding powder, injectable solution


Frequency not reported: Anorexia, zinc deficiency, hypercalcemia, hyperuricemia


Frequency not reported: Hypotension, cardiac rhythm irregularities, transient drop in systolic and diastolic blood pressure, thrombophlebitis


Frequency not reported: Cheilosis, nausea, vomiting, diarrhea, circumoral paresthesia


Frequency not reported: Glycosuria, proteinuria, microscopic hematuria, large epithelial cells in urinary sediment


Frequency not reported: Acute necrosis of proximal tubules (which may result in fatal nephrosis), infrequent changes in distal tubules and glomeruli, nephrotoxicity, damage to the reticuloendothelial system with hemorrhagic tendencies (from excessive dosages)


Frequency not reported: Transient bone marrow depression, anemia


Increases in SGOT and SGPT usually return to normal within 48 hours after treatment discontinuation.

Common (1% to 10%): Mild increases in SGOT and SGPT

Nervous system

Frequency not reported: Tremors, headache, tingling, numbness


Frequency not reported: Rash, exfoliative dermatitis and other toxic skin and mucus membrane reactions


Frequency not reported: Fever, malaise, fatigue, febrile reactions


Frequency not reported: Chills, myalgia, arthralgia


Frequency not reported: Histamine-like reactions (sneezing, nasal congestion, lacrimation)


Frequency not reported: Pain at intramuscular injection site

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Edetate Calcium Disodium