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Generic Name: azelastine and fluticasone nasal (AY zel AS teen and floo TIK a sone)
Brand Names: Dymista
Dymista (azelastine and fluticasone nasal spray) treats nasal congestion, sneezing, and runny nose caused by seasonal allergies. Includes Dymista side effects, interactions and indications.
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Drug Information:
Dymista nasal spray contains a combination of azelastine and fluticasone. Azelastine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Fluticasone is a steroid that prevents the release of substances in the body that cause inflammation. Dymista nasal spray is used to treat nasal symptoms such as congestion, sneezing, and runny nose caused by seasonal allergies. Dymista nasal spray is for use in adults and children who are at least 6 years old. Learn more

Dymista Side Effects

Dymista Side Effects

Note: This document contains side effect information about azelastine / fluticasone nasal. Some of the dosage forms listed on this page may not apply to the brand name Dymista.

For the Consumer

Applies to azelastine/fluticasone nasal: nasal spray

Along with its needed effects, azelastine/fluticasone nasal may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking azelastine/fluticasone nasal:

Less common

  • Bloody nose
  • body aches or pain
  • chills
  • cold or flu-like symptoms
  • congestion
  • cough or hoarseness
  • difficulty with breathing
  • dryness or soreness of the throat
  • ear congestion
  • fever
  • headache
  • loss of voice
  • nasal congestion
  • runny nose
  • sneezing
  • tender, swollen glands in the neck
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes

Incidence not known

  • Blindness
  • bloody mucus or unexplained nosebleeds
  • blurred vision
  • chest pain
  • darkening of the skin
  • decreased vision
  • delayed wound healing
  • diarrhea
  • difficult or labored breathing
  • dizziness
  • eye pain
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • hives, itching, or skin rash
  • lack or slowing of normal growth in children
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • loss of appetite
  • mental depression
  • nausea or vomiting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • sleepiness or unusual drowsiness
  • sore mouth or tongue
  • sores inside the nose
  • tearing
  • tightness in the chest
  • white patches in the mouth or on the tongue

Some side effects of azelastine/fluticasone nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Change in taste
  • loss of taste

Incidence not known

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • change in sense of smell
  • changes in vision
  • discharge or excessive tearing
  • hives or welts
  • irritation at the application site
  • loss of smell
  • mental or mood changes
  • redness of the skin
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid

For Healthcare Professionals

Applies to azelastine / fluticasone nasal: nasal spray


The most commonly reported side effects were headache, pyrexia, cough, nasal congestion, and rhinitis.



Postmarketing reports: Hypersensitivity reactions (including angioedema, skin rash, edema of the face and tongue, pruritus, urticaria, bronchospasm, wheezing, dyspnea, and anaphylaxis/anaphylactoid reactions)



Frequency not reported: Hypothalamic-pituitary-adrenal (HPA) axis effects


Common (1% to 10%): Viral infection


Frequency not reported: Immunosuppression, Candida albicans infection


Common (1% to 10%): Epistaxis, cough, nasal congestion, rhinitis, upper respiratory tract infection, pharyngitis


Postmarketing reports: Nasal sores


Rare (0.01% than 0.1%): Nasal septal perforation, nasal ulcer, sore throat, throat irritation and dryness, cough, hoarseness, voice changes

Nervous system

Common (1% to 10%) Dysgeusia, headache

Uncommon (0.1% to 1%): Somnolence


Postmarketing reports: Confusion, involuntary muscle contractions, paraesthesia, parosmia, disturbance or loss of sense of smell and/or taste



Postmarketing reports: Abnormal vision, xerophthalmia


Postmarketing reports: Dryness, irritation, conjunctivitis, blurred vision, glaucoma, increased intraocular pressure, cataracts


Common (1% to 10%): Diarrhea

Rare (0.01% than 0.1%): Dry mouth

Very rare (less than 0.01%): Nausea


Common (1% to 10%): Pyrexia, pain

Very rare (less than 0.01%): Fatigue


Frequency not reported: Impaired wound healing



Postmarketing reports: Atrial fibrillation, chest pain, palpitations



Postmarketing reports: Application site irritation



Postmarketing reports: Urinary retention



Postmarketing reports: Growth suppression

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Dymista