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Generic Name: dupilumab (doo PIL ue mab)
Brand Names: Dupixent
Dupixent (dupilumab) is used to treat moderate-to-severe eczema (atopic dermatitis), asthma, and chronic rhinosinusitis with nasal polyposis. Includes Dupixent side effects, interactions and indications.
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Drug Information:
Dupixent (dupilumab) is used to treat moderate-to-severe eczema (atopic dermatitis) that cannot be controlled with topical medicines (for use on the skin). Dupixent is also used together with other medications to treat moderate-to-severe asthma that is not controlled with other asthma medicines. Dupixent is used for asthma or eczema in adults and children at least 12 years old. Do not use this medicine to treat an asthma attack. Use a rescue inhaler. Dupixent is used only in adults to treat a condition called chronic rhinosinusitis (long-term sinus inflammation) that is associated with nasal polyps. Learn more

Dupixent Side Effects

Dupixent Side Effects

Note: This document contains side effect information about dupilumab. Some of the dosage forms listed on this page may not apply to the brand name Dupixent.

In Summary

Common side effects of Dupixent include: allergic conjunctivitis, conjunctivitis, injection site reaction, ophthalmic inflammation, and eye irritation. Other side effects include: oral herpes simplex infection. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dupilumab: subcutaneous solution

Along with its needed effects, dupilumab (the active ingredient contained in Dupixent) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking dupilumab:

More common

  • Blistering or crusting of the skin
  • itchiness, redness of the eyes
  • excessive tearing
  • painful cold sores or blisters on the lips, nose, eyes, or genitals
  • reddening of the skin
  • scaly patches on the skin
  • sores or white patches on the lips, mouth, or throat

Less common

  • Burning or dry eyes
  • fever
  • pain, swelling of the eye or eyelid

Some side effects of dupilumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to dupilumab: subcutaneous solution


Very common (10% or more): Conjunctivitis (cluster includes conjunctivitis, allergic conjunctivitis, bacterial conjunctivitis, viral conjunctivitis, giant papillary conjunctivitis, eye irritation, and eye inflammation) (10%)

Common (1% to 10%): Blepharitis, eye pruritus, keratitis (e.g., keratitis, ulcerative keratitis, allergic keratitis, atopic keratoconjunctivitis, ophthalmic herpes simplex), dry eye


Very common (10% or more): Injection site reactions (10%)


Common (1% to 10%): Herpes simplex viral infections (e.g., herpes simplex, genital herpes, herpes simplex otitis externa, herpes virus infection), immunogenicity

Very rare (less than 0.01%): Serum sickness/serum sickness-like reactions


Uncommon (0.1% to 1%): Hypersensitivity


Common (1% to 10%): Oral herpes


Common (1% to 10%): Eosinophilia

Nervous system

Common (1% to 10%): Headache

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Dupixent