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Generic Name: bazedoxifene and conjugated estrogens (BA ze DOX i feen and KON joo GAY ted ES troe jens)
Brand Names: Duavee
Duavee (bazedoxifene/conjugated estrogens) is used to treat hot flashes and prevent postmenopausal osteoporosis. Includes Duavee side effects, interactions and indications.
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Drug Information:
Duavee contains a combination of bazedoxifene and conjugated estrogens. Bazedoxifene blocks estrogen from reaching certain cells in the uterine lining, to protect against overgrowth of uterine tissue. Estrogen is a female sex hormone produced by the ovaries. Conjugated strogens are a mixture of estrogen hormones. Duavee is used short-term in women after menopause to treat moderate to severe hot flashes, and to prevent osteoporosis. Duavee is used in women who have NOT had a hysterectomy (uterus removed). Learn more

Duavee Side Effects

Duavee Side Effects

Note: This document contains side effect information about bazedoxifene / conjugated estrogens. Some of the dosage forms listed on this page may not apply to the brand name Duavee.

In Summary

More frequent side effects include: diarrhea, dizziness, muscle spasm, and nausea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bazedoxifene/conjugated estrogens: oral tablet


Oral route (Tablet)

Women taking bazedoxifene/conjugated estrogens should not take additional estrogens. There is an increased risk of endometrial cancer in women with a uterus that use unopposed estrogens. Estrogen therapy should not be used for the prevention of cardiovascular disease or dementia. The Women's Health Initiative (WHI) estrogen-alone substudy reported increased risks of stroke and deep vein thrombosis (DVT) with daily conjugated estrogens therapy compared with placebo. The WHI Memory Study (WHIMS) estrogen-alone ancillary study of WHI reported an increased risk of probable dementia in postmenopausal women 65 years of age and older with daily conjugated estrogens therapy compared with placebo.

Along with its needed effects, bazedoxifene / conjugated estrogens may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bazedoxifene / conjugated estrogens:

Incidence not known

  • Acid or sour stomach
  • anxiety
  • backache
  • belching
  • bloating
  • change in vaginal discharge
  • chest pain
  • chills
  • clear or bloody discharge from the nipple
  • confusion
  • constipation
  • cough
  • darkened urine
  • difficulty with speaking
  • dimpling of the breast skin
  • dizziness or lightheadedness
  • double vision
  • fainting
  • fast heartbeat
  • fever
  • full or bloated feeling or pressure in the stomach
  • headache
  • heartburn
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • indigestion
  • inverted nipple
  • loss of appetite
  • lump in the breast or under the arm
  • nausea
  • pain or feeling of pressure in the pelvis
  • pain, redness, or swelling in the arm or leg
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • persistent crusting or scaling of the nipple
  • redness or swelling of the breast
  • slow speech
  • sore on the skin of the breast that does not heal
  • stomach discomfort, upset, or pain
  • sudden shortness of breath or troubled breathing
  • swelling of the abdominal or stomach area
  • vaginal bleeding
  • vomiting
  • yellow eyes or skin

Some side effects of bazedoxifene / conjugated estrogens may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • muscle spasm
  • throat pain
  • upper abdominal or stomach pain

Less common

  • Neck pain

For Healthcare Professionals

Applies to bazedoxifene / conjugated estrogens: oral tablet


The most common side effect were muscle spasms, nausea, diarrhea, dyspepsia, upper abdominal pain, oropharyngeal pain, dizziness, and neck pain.


Common (1% to 10%): Hypertension

Frequency not reported: Venous thromboembolism, deep vein thrombosis


Common (1% to 10%): Nausea, diarrhea, dyspepsia, upper abdominal pain


Common (1% to 10%): Muscle spasms, neck pain

Uncommon (0.1% to 1%): Tendonitis

Nervous system

Common (1% to 10%): Dizziness, hypoesthesia


Frequency not reported: Retinal vein thrombosis

Bazedoxifene Monotherapy:

Postmarketing reports: Reduced visual acuity, blurred vision, photopsia, visual field defect, visual impairment, dry eye, eyelid edema, blepharospasm, eye pain, eye swelling


Common (1% to 10%): Oropharyngeal pain, sinus headache, cough, dyspnea, nasal congestion, pharyngolaryngeal pain, allergic rhinitis, sinus congestion

Frequency not reported: Pulmonary embolism


Common (1% to 10%): Blood triglycerides increased


Common (1% to 10%): Dysuria, vaginal discharge, vulvovaginal pruritus

Uncommon (0.1% to 1%): pelvic pain


Uncommon (0.1% to 1%): Cholecystitis


Common (1% to 10%): Acne, alopecia, contact dermatitis, dry skin, pruritus, rash


Common (1% to 10%): Breast pain, breast tenderness

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Duavee