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Generic Name: avatrombopag (A va TROM boe pag)
Brand Names: Doptelet
Doptelet (avatrombopag) is used to treat thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a medical or dental procedure, and patients with chronic immune thrombocytopenia. Includes Doptelet side effects, interactions and indications.
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Drug Information:
Doptelet (avatrombopag) is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure. A low platelet count increases the risk of excessive bleeding during certain medical procedures. Avatrombopag increases the production of platelets by your body to help prevent too much bleeding. Doptelet is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough. Learn more

Doptelet Side Effects

Doptelet Side Effects

Note: This document contains side effect information about avatrombopag. Some of the dosage forms listed on this page may not apply to the brand name Doptelet.

For the Consumer

Applies to avatrombopag: oral tablet

Along with its needed effects, avatrombopag (the active ingredient contained in Doptelet) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking avatrombopag:

Less common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • rapid weight gain
  • tingling of the hands or feet
  • unusual weight gain or loss


  • Confusion
  • decreased urine output
  • dizziness
  • fast or irregular heartbeat
  • headache
  • increased thirst
  • loss of consciousness
  • muscle pain or cramps
  • nausea
  • pale skin
  • seizures
  • swelling of the face, ankles, or hands
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Difficulty breathing
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • vision changes

Some side effects of avatrombopag may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Fever
  • stomach pain


  • Difficulty in moving
  • joint pain or swelling
  • muscle ache or stiffness

For Healthcare Professionals

Applies to avatrombopag: oral tablet


The most common serious adverse reactions were headache and hyponatremia.

Nervous system

Very common (10% or more): Headache (up to 31%)


Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%)

Common (1% to 10%): Edema peripheral


Very common (10% or more): Contusion (26%)

Common (1% to 10%): Thromboembolic events


Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%)


Very common (10% or more): Arthralgia (13%)

Frequency not reported: Myalgia


Very common (10% or more): Gingival bleeding (13%)

Common (1% to 10%): Abdominal pain, nausea


Very common (10% or more): Petechiae (11%)


Uncommon (0.1% to 1%): Hyponatremia


Frequency not reported: Anemia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Doptelet