Note: This document contains side effect information about olsalazine. Some of the dosage forms listed on this page may not apply to the brand name Dipentum.
Applies to olsalazine: oral capsule
Along with its needed effects, olsalazine (the active ingredient contained in Dipentum) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking olsalazine:
Some side effects of olsalazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to olsalazine: oral capsule
The most commonly reported side effects included diarrhea, abdominal pain, cramps, nausea, and headaches.
Compared to patients given placebo, increased frequency and intensity of diarrhea was reported in patients given 500 mg orally 2 times a day who were also receiving pelvic radiation.
Very common (10% or more): Diarrhea (up to 17%), abdominal pain (up to 10.1%), cramps (10.1%)
Common (1% to 10%): Bloating, heartburn, loose stools, nausea, rectal bleeding, stomatitis, upset stomach, vomiting
Uncommon (0.1% to 1%): Dyspepsia
Frequency not reported: Abdominal pain upper, diarrhea with dehydration, dry mouth, epigastric discomfort, exacerbation/flare in symptoms, flatulence, increased blood in stool, pancreatitis, rectal discomfort
Common (1% to 10%): Dizziness, headache, lightheadedness, vertigo
Uncommon (0.1% to 1%): Paresthesia
Frequency not reported: Drowsiness, lethargy, peripheral neuropathy, tremors
Common (1% to 10%): Itching, rash
Uncommon (0.1% to 1%): Alopecia, photosensitivity/photosensitivity reaction, pruritus, urticaria
Frequency not reported: Erythema, erythema nodosum
Common (1% to 10%): Depression, insomnia
Frequency not reported: Irritability, mood swings
Common (1% to 10%): Arthralgia, joint pain
Uncommon (0.1% to 1%): Myalgia
Frequency not reported: Muscle cramps
Common (1% to 10%): Upper respiratory infection
Uncommon (0.1% to 1%): Dyspnea
Frequency not reported: Bronchospasm, interstitial lung/pulmonary disease, shortness of breath
Common (1% to 10%): Anorexia
Postmarketing reports: Elevated lactate dehydrogenase (LDH)
Patients who developed granulomatous hepatitis, nonspecific, reactive hepatitis, or mild cholestatic hepatitis had complete recovery after treatment was withdrawn.
Uncommon (0.1% to 1%): Hepatic enzyme increased
Rare (0.01% to 0.1%): Granulomatous hepatitis, nonspecific, reactive hepatitis
Frequency not reported: ALT elevated beyond normal range, AST elevated beyond normal range, hepatitis, increased bilirubin, mild cholestatic hepatitis
Postmarketing reports: Cholestatic jaundice, cirrhosis, elevated alkaline phosphatase, elevated GGT, hepatic function changes, hepatocellular damage, hepatotoxicity, jaundice, liver failure, liver necrosis
Uncommon (0.1% to 1%): Thrombocytopenia
Frequency not reported: Anemia, aplastic anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, leukopenia, lymphopenia, neutropenia, pancytopenia, reticulocytosis
Uncommon (0.1% to 1%): Tachycardia
Frequency not reported: Chest pains, heart block second degree, hot flashes, hypertension, myocarditis, orthostatic hypotension, palpitations, pericarditis, peripheral edema
A patient developed thyroid disease 9 days after starting treatment and was given propranolol radioactive iodine; the patient then developed nausea and shortness of breath and died 5 days later with signs/symptoms of acute diffuse myocarditis.
Uncommon (0.1% to 1%): Pyrexia
Frequency not reported: Chills, fatigue, fever, miscellaneous side effects, rigors, tinnitus
Frequency not reported: Dysuria, frequency/urinary frequency, hematuria, impotence, menorrhagia, proteinuria
Frequency not reported: Blurred vision, dry eyes, watery eyes
Frequency not reported: Interstitial nephritis, nephrotic syndrome
Frequency not reported: Angioneurotic edema
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Dipentum