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Generic Name: olsalazine (ole SAL a zeen)
Brand Name: Dipentum
Physician reviewed Dipentum patient information - includes Dipentum description, dosage and directions.
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Drug Information:
Dipentum is used to treat ulcerative colitis. Dipentum may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. You should not use Dipentum if you are allergic to Dipentum or to salicylates such as aspirin, Novasal, Doan's Extra Strength, Salflex, Tricosal, and others. Tell your doctor if you have ever had: asthma or allergies; Learn more

Dipentum Side Effects

Dipentum Side Effects

Note: This document contains side effect information about olsalazine. Some of the dosage forms listed on this page may not apply to the brand name Dipentum.

For the Consumer

Applies to olsalazine: oral capsule

Along with its needed effects, olsalazine (the active ingredient contained in Dipentum) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking olsalazine:


  • Back or stomach pain (severe)
  • bloody diarrhea
  • fast heartbeat
  • fever
  • nausea or vomiting
  • skin rash
  • swelling of the stomach
  • yellow eyes or skin

Some side effects of olsalazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain or upset
  • diarrhea
  • loss of appetite

Less common

  • Aching joints and muscles
  • acne
  • anxiety or depression
  • dizziness or drowsiness
  • headache
  • trouble in sleeping

For Healthcare Professionals

Applies to olsalazine: oral capsule


The most commonly reported side effects included diarrhea, abdominal pain, cramps, nausea, and headaches.


Compared to patients given placebo, increased frequency and intensity of diarrhea was reported in patients given 500 mg orally 2 times a day who were also receiving pelvic radiation.

Very common (10% or more): Diarrhea (up to 17%), abdominal pain (up to 10.1%), cramps (10.1%)

Common (1% to 10%): Bloating, heartburn, loose stools, nausea, rectal bleeding, stomatitis, upset stomach, vomiting

Uncommon (0.1% to 1%): Dyspepsia

Frequency not reported: Abdominal pain upper, diarrhea with dehydration, dry mouth, epigastric discomfort, exacerbation/flare in symptoms, flatulence, increased blood in stool, pancreatitis, rectal discomfort

Nervous system

Common (1% to 10%): Dizziness, headache, lightheadedness, vertigo

Uncommon (0.1% to 1%): Paresthesia

Frequency not reported: Drowsiness, lethargy, peripheral neuropathy, tremors


Common (1% to 10%): Itching, rash

Uncommon (0.1% to 1%): Alopecia, photosensitivity/photosensitivity reaction, pruritus, urticaria

Frequency not reported: Erythema, erythema nodosum


Common (1% to 10%): Depression, insomnia

Frequency not reported: Irritability, mood swings


Common (1% to 10%): Arthralgia, joint pain

Uncommon (0.1% to 1%): Myalgia

Frequency not reported: Muscle cramps


Common (1% to 10%): Upper respiratory infection

Uncommon (0.1% to 1%): Dyspnea

Frequency not reported: Bronchospasm, interstitial lung/pulmonary disease, shortness of breath


Common (1% to 10%): Anorexia

Postmarketing reports: Elevated lactate dehydrogenase (LDH)


Patients who developed granulomatous hepatitis, nonspecific, reactive hepatitis, or mild cholestatic hepatitis had complete recovery after treatment was withdrawn.

Uncommon (0.1% to 1%): Hepatic enzyme increased

Rare (0.01% to 0.1%): Granulomatous hepatitis, nonspecific, reactive hepatitis

Frequency not reported: ALT elevated beyond normal range, AST elevated beyond normal range, hepatitis, increased bilirubin, mild cholestatic hepatitis

Postmarketing reports: Cholestatic jaundice, cirrhosis, elevated alkaline phosphatase, elevated GGT, hepatic function changes, hepatocellular damage, hepatotoxicity, jaundice, liver failure, liver necrosis


Uncommon (0.1% to 1%): Thrombocytopenia

Frequency not reported: Anemia, aplastic anemia, eosinophilia, granulocytopenia, hemolysis, hemolytic anemia, leukopenia, lymphopenia, neutropenia, pancytopenia, reticulocytosis


Uncommon (0.1% to 1%): Tachycardia

Frequency not reported: Chest pains, heart block second degree, hot flashes, hypertension, myocarditis, orthostatic hypotension, palpitations, pericarditis, peripheral edema

A patient developed thyroid disease 9 days after starting treatment and was given propranolol radioactive iodine; the patient then developed nausea and shortness of breath and died 5 days later with signs/symptoms of acute diffuse myocarditis.


Uncommon (0.1% to 1%): Pyrexia

Frequency not reported: Chills, fatigue, fever, miscellaneous side effects, rigors, tinnitus


Frequency not reported: Dysuria, frequency/urinary frequency, hematuria, impotence, menorrhagia, proteinuria


Frequency not reported: Blurred vision, dry eyes, watery eyes


Frequency not reported: Interstitial nephritis, nephrotic syndrome


Frequency not reported: Angioneurotic edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Dipentum