Note: This document contains side effect information about valsartan. Some of the dosage forms listed on this page may not apply to the brand name Diovan.
Common side effects of Diovan include: dizziness and increased serum potassium. Other side effects include: hypotension. See below for a comprehensive list of adverse effects.
Applies to valsartan: oral tablet
Oral route (Capsule; Tablet; Solution)
When pregnancy is detected, discontinue valsartan as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
Along with its needed effects, valsartan (the active ingredient contained in Diovan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking valsartan:
Incidence not known
Some side effects of valsartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to valsartan: oral capsule, oral tablet
Very common (10% or more): Headache (up to 14%), dizziness (up to 14%)
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Vertigo
Common (1% to 10%): Cough
Uncommon (0.1% to 1%): Dyspnea
A 71-year-old woman experienced an acute onset of angioedema and a photosensitive pruritic rash after 3 months of valsartan (the active ingredient contained in Diovan) therapy. Her symptoms dissipated and the rash resolved after treatment with subcutaneous epinephrine, intravenous methylprednisolone, diphenhydramine, and emollient cream.
A unique case of dose-dependent, valsartan-induced angioedema has been reported. Two hours after initiating a dose increase (160 to 320 mg/day) of valsartan, a patient developed angioedema (i.e., swelling of lips and tongue). Symptoms resolved following a reduction in dose to the original dosage of 160 mg/day.
Very rare (less than 0.01%): Angioedema
Common (1% to 10%): Symptomatic hypotension in 5.5% of heart failure patients in clinical trials
Rare (less than 0.1%): Palpitations, chest pain
Frequency not reported: Dizziness related to orthostatic hypotension
Postmarketing reports: Heart failure
Common (1% to 10%): Hyperkalemia, hyponatremia
Frequency not reported: Impaired renal function, increases in serum creatinine concentrations, blood urea nitrogen, and potassium
Postmarketing reports: Renal failure
Rare (less than 0.1%): Pruritus, rash, alopecia
Postmarketing reports: Bullous dermatitis
Uncommon (0.1% to 1%): Diarrhea, constipation, dry mouth, dyspepsia, anorexia, nausea, vomiting, flatulence
Postmarketing reports: Taste disturbance (i.e., altered sensitivity of basic tastes) has been reported following repeated dosing
Common (1% to 10%): Back pain, muscle cramps, myalgias
Very rare (less than 0.01%): Rhabdomyolysis
Frequency not reported: Anxiety, insomnia, paresthesias, somnolence
Very rare (less than 0.01%): Impotence
Uncommon (0.1% to 1%): Hematocrit decreased, hemoglobin decreased, neutropenia
Postmarketing reports: Thrombocytopenia, vasculitis
Valsartan-associated hepatotoxicity in a patient with hepatitis B surface antigen (HBs-Ag) positivity (without signs and symptoms) has been reported. After 1 month of treatment with valsartan (the active ingredient contained in Diovan) this patient developed pruritic erythematous skin changes, nausea, jaundice, right subcostal abdominal pain, elevated liver enzymes, and mild hepatomegaly. Signs and symptoms of hepatotoxicity resolved within 2 to 3 weeks following discontinuation of valsartan and the patient remained asymptomatic after 6 months of follow-up.
Very rare (less than 0.01%): Hepatitis
Frequency not reported: Hepatic enzymes increased
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Diovan Hct