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Diazoxide

Generic Name: diazoxide (oral) (DYE az OX ide)
Brand Name: Proglycem, Hyperstat
Physician reviewed diazoxide (oral) patient information - includes diazoxide description, dosage and directions.
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Drug Information:
Diazoxide raises blood sugar by slowing the release of insulin from the pancreas. Diazoxide is used to treat low blood sugar (hypoglycemia) caused by certain cancers or other conditions that can make the pancreas release too much insulin. diazoxide is for use in adults and children as young as infants. Diazoxide may also be used for purposes not listed in this medication guide. You should not take this medicine to treat occasional low blood sugar caused by diet. You should not take diazoxide if you are allergic to diazoxide or to certain heart or blood pressure medicines such as hydrochlorothiazide (HCTZ), HydroDiuril, Hyzaar, Lopressor HCT, Vaseretic, Zestoretic, and others. Learn more

Diazoxide Side Effects

Diazoxide Side Effects

For the Consumer

Applies to diazoxide: oral suspension

Along with its needed effects, diazoxide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking diazoxide:

Rare

  • Chest pain

Incidence not known

  • Abdominal or stomach pain
  • black, tarry stools
  • blood in the urine
  • bloody nose
  • blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • extreme thirst
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • flushed, dry skin
  • fruit-like breath odor
  • heavier menstrual periods
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • nausea
  • pinpoint red spots on the skin
  • seizures
  • skin rash
  • stomachache
  • sweating
  • troubled breathing
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • urinating large amounts or urinating very little
  • vomiting
  • weakness

Some side effects of diazoxide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Increased hair growth, especially on the forehead, back, arms, and legs

Incidence not known

  • Loss of appetite
  • loss of taste
  • weight loss

For Healthcare Professionals

Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension

General

The most common reactions reported following diazoxide administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).

Cardiovascular

Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.

Nervous system

Nervous system affects reported following diazoxide administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.

Gastrointestinal

Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.

Metabolic

Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.

Respiratory

Respiratory effects including dyspnea, cough and choking sensation have been reported.

Hypersensitivity

Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide have been reported.

Other

Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Diazoxide