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Definity

Generic Name: perflutren (per FLOO tren)
Brand Name: Definity, Optison
Physician reviewed Definity patient information - includes Definity description, dosage and directions.
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Drug Information:
Definity is an ultrasound contrast agent that is used to improve the quality of an echocardiogram (ultrasound of the heart). This medicine works by changing the way ultrasound waves travel within your heart. This helps the ultrasound portray a sharper image of your heart. Definity is used to allow certain segments of the heart to be seen more clearly on an echocardiogram. Definity may also be used for purposes not listed in this medication guide. You should not be treated with Definity if you have a genetic heart condition called "cardiac shunt." Learn more

Definity Side Effects

Definity Side Effects

Note: This document contains side effect information about perflutren. Some of the dosage forms listed on this page may not apply to the brand name Definity.

For the Consumer

Applies to perflutren: intravenous suspension

Warning

Intravenous route (Suspension)

Serious cardiopulmonary reactions, including fatalities, have occurred during or following perflutren-containing microsphere administration with the most serious reactions occurring within 30 minutes of administration. Assess all patients for any condition that precludes use of this product. Always have resuscitation equipment and trained personnel available.

Along with its needed effects, perflutren (the active ingredient contained in Definity) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking perflutren:

Less common

  • Chest pain
  • feeling of warmth
  • fever or chills
  • redness of the face, neck, arms, and occasionally, upper chest
  • trouble breathing

Rare

  • Hives or welts, itching, or skin rash
  • fast, irregular, pounding, or racing heartbeat or pulse
  • redness of the skin

Incidence not known

  • Blurred vision
  • chest discomfort
  • cold, clammy skin
  • confusion
  • convulsions
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fast, weak pulse
  • feeling of warmth
  • headache
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • nervousness
  • no blood pressure or pulse
  • noisy breathing
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • stopping of heart
  • sweating
  • tightness in the chest
  • troubled swallowing
  • unconsciousness
  • unusual tiredness or weakness

Some side effects of perflutren may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • cough
  • discomfort at the injection site
  • nausea or vomiting
  • sore throat
  • stuffy or runny nose

Rare

  • Back pain
  • body or muscle aches
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in color vision
  • continuing ringing or buzzing or other unexplained noise in the ears
  • difficulty with moving
  • difficulty seeing at night
  • discoloration of the skin at the injection site
  • dry mouth
  • hearing loss
  • increased sensitivity of the eyes to sunlight
  • muscle pain or stiffness

For Healthcare Professionals

Applies to perflutren: intravenous suspension

General

The most frequently reported adverse reactions were headache, nausea and/or vomiting, warm sensation or flushing, dizziness, and back pain.

Cardiovascular

Common (1% to 10%): Chest pain

Uncommon (0.1% to 1%): Abnormal ECGs, bradycardia, tachycardia, palpitation, hypertension, hypotension

Postmarketing reports: Fatal cardiac arrest, shock, syncope, symptomatic arrhythmias (atrial fibrillation, tachycardia, bradycardia, supraventricular tachycardia, ventricular fibrillation/tachycardia), hypertension, hypotension

Serious but uncommon cardiopulmonary reactions, including fatalities, have been reported during or following administration of this medication. Most serious reactions occurred within 30 minutes of administration.

QTc prolongation of greater than 30 milliseconds occurred in 29% (64/221) of patients evaluated. Of these patients 72% (46/64) were further evaluated and 39% (18/46) were found to have cardiac rhythm changes. (Definity(R))

Dermatologic

Common (1% to 10%): Flushing

Uncommon (0.1% to 1%): Pruritus, rash, erythematous rash, urticaria, increased sweating, dry skin

Gastrointestinal

Common (1% to 10%): Nausea

Uncommon (0.1% to 1%): Dyspepsia, dry mouth, tongue disorder, abdominal pain, diarrhea, vomiting

Musculoskeletal

Common (1% to 10%): Back pain

Uncommon (0.1% to 1%): Arthralgia

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Leg cramps, hypertonia, vertigo, paresthesia, dizziness, taste perversion

Postmarketing Reports: Coma, loss of consciousness, convulsion, seizure, transient ischemic attack, agitation, tremor, vision blurred, dizziness, headache, fatigue

Renal

Common (1% to 10%): Renal pain

Genitourinary

Uncommon (0.1% to 1%): Albuminuria

Hematologic

Uncommon (0.1% to 1%): Granulocytosis, leukocytosis, leukopenia, eosinophilia, hematoma

Local

Uncommon (0.1% to 1%): Injection site reaction

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, abnormal vision

Other

Uncommon (0.1% to 1%): Decreased hearing

Respiratory

Uncommon (0.1% to 1%): Coughing, hypoxia, pharyngitis, rhinitis, dyspnea

Postmarketing reports: Fatal respiratory arrest, dyspnea, hypoxia, respiratory distress, stridor, wheezing

Hypersensitivity

Postmarketing reports of anaphylactic/anaphylactoid reactions have included: anaphylactic shock, hypersensitivity, bronchospasm, throat tightness, angioedema, edema (pharyngeal, palatal, mouth, peripheral, localized), swelling (face, eye, lip, tongue, upper airway), facial hypoesthesia, rash, urticaria, pruritus, flushing, and erythema.

Postmarketing reports: Anaphylactic/anaphylactoid reactions

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Definity