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Generic Name: daratumumab (DAR a TOOM ue mab)
Brand Names: Darzalex
Darzalex (daratumumab) is used to treat previously treated multiple myeloma. Includes Darzalex uses, side effects, interactions and indications.
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Drug Information:
Darzalex (daratumumab) is a monoclonal antibody that blocks a certain protein in the body that can affect tumor cell growth. Monoclonal antibodies are made to target and destroy only certain cells in the body. This may help to protect healthy cells from damage. Darzalex is used to treat multiple myeloma (bone marrow cancer). Daratumumab is usually given after other treatments have failed. Darzalex is sometimes used in combination with other cancer medicines plus a steroid medicine called dexamethasone. Learn more

Darzalex Side Effects

Darzalex Side Effects

Note: This document contains side effect information about daratumumab. Some of the dosage forms listed on this page may not apply to the brand name Darzalex.

For the Consumer

Applies to daratumumab: intravenous solution

Along with its needed effects, daratumumab (the active ingredient contained in Darzalex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking daratumumab:

More common

  • Blurred vision
  • body aches or pain
  • chest pain or tightness
  • chills
  • dizziness
  • ear congestion
  • fever
  • facial swelling
  • headache
  • loss of voice
  • nausea
  • nervousness
  • pounding in the ears
  • slow or fast heartbeat
  • sneezing
  • sore throat
  • stuffy or runny nose
  • trouble breathing
  • vomiting

Less common

  • Confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • painful blisters on the trunk of body
  • skin rash, hives, or itching
  • sweating
  • unusual tiredness or weakness

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • cough
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising

Some side effects of daratumumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • constipation
  • diarrhea
  • difficulty with moving
  • joint pain
  • loss of appetite
  • muscle pain or stiffness
  • pain in the arms or legs

For Healthcare Professionals

Applies to daratumumab: intravenous solution


Very common (10% or more): Hypertension (10%)


Very common (10% or more): Nausea (27%), diarrhea (16%), constipation (15%), vomiting (14%)


Very common (10% or more): Lymphopenia (72%), neutropenia (60%), thrombocytopenia (48%), anemia (45%)


Common (1% to 10%): Pneumonia (e.g., streptococcal pneumonia, lobar pneumonia), herpes zoster reactivation


Very common (10% or more): Infusion reaction (48%)


Very common (10% or more): Decreased appetite (15%)


Very common (10% or more): Back pain (23%), arthralgia (17%), pain in extremity (15%), musculoskeletal chest pain (12%)

Nervous system

Very common (10% or more): Headache (12%)


Very common (10% or more): Cough (21%), upper respiratory tract infection (20%), nasal congestion (17%), dyspnea (15%), nasopharyngitis (15%), vomiting (14%)

Common (1% to 10%): Bronchospasm, dyspnea, hypoxia

Uncommon (0.1% to 1%): Allergic rhinitis allergic, throat irritation

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Darzalex