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Generic Name: antivenin (Crotalidae) polyvalent (AN tye VEN in (kroe TAL i dee) POL ee VAY lent)
Brand Name: Anavip, CroFab
Physician reviewed CroFab patient information - includes CroFab description, dosage and directions.
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Drug Information:
Crotalidae antivenin is an anti-venom used to treat a person who has been bitten by a venomous snake such as a rattlesnake or Water Moccasin. CroFab may also be used for purposes not listed in this medication guide. If possible before you receive CroFab, tell your doctor if you are allergic to any foods, animals, or other allergens. In an emergency situation it may not be possible before you are treated to tell your caregivers about your health conditions or if you are pregnant or breast feeding. Make sure any doctor caring for you afterward knows that you have received this medication. Learn more

Crofab Side Effects

CroFab Side Effects

Note: This document contains side effect information about antivenin (crotalidae) polyvalent. Some of the dosage forms listed on this page may not apply to the brand name CroFab.

For the Consumer

Applies to antivenin (crotalidae) polyvalent: intravenous powder for solution

Along with its needed effects, antivenin (crotalidae) polyvalent (the active ingredient contained in CroFab) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking antivenin (crotalidae) polyvalent:

Less common

  • Bruising
  • cough
  • difficulty in moving
  • difficulty swallowing
  • dizziness
  • fast heartbeat
  • feeling of discomfort
  • fever
  • hives, itching, skin rash
  • joint pain or swelling
  • large, flat, blue or purplish patches in the skin
  • muscle cramps, pain, or stiffness
  • problems with bleeding or clotting
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • swollen lymph glands
  • tightness in the chest
  • unusual tiredness or weakness


  • Blurred vision
  • chest pain or discomfort
  • confusion
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • noisy breathing
  • rapid, shallow breathing
  • sweating

Incidence not known

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • itching, swelling, redness, tenderness, or hard lump at the injection site
  • pinpoint red spots on the skin
  • tremor
  • unusual bleeding or bruising

Some side effects of antivenin (crotalidae) polyvalent may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Back pain
  • loss of appetite
  • nausea
  • nervousness
  • small lumps under the skin
  • weight loss


  • Bone pain
  • feeling cold
  • headache

For Healthcare Professionals

Applies to antivenin (crotalidae) polyvalent: injectable solution, intravenous powder for injection


The most common adverse events were urticaria and rash.


Very common (10% or more): Urticaria (16%), rash (11%)

Common (1% to 10%): Pruritus, cellulitis, subcutaneous nodule, ecchymosis

Postmarketing reports: Erythema, hyperhidrosis, angioedema


Allergic reaction consisted of urticaria, dyspnea, and wheezing. Serum sickness included urticaria, cough, rash, pruritus, and urticaria. Acute allergic reactions manifested as anxiety, bronchospasm, chills, edema, fever, hypotension, pruritus, rash, urticaria, voice alteration, and/or wheezing.

Common (1% to 10%): Allergic reaction, serum sickness

Postmarketing reports: Acute allergic reactions including anaphylaxis or anaphylactoid reactions, delayed allergic reaction.


Common (1% to 10%): Coagulation disorder

Postmarketing reports: Delayed or recurrent coagulopathy or thrombocytopenia, thrombocytopenia refractory to treatment, bleeding


Common (1% to 10%): Hypotension

Postmarketing reports: Tachycardia

Nervous system

Common (1% to 10%): General paresthesia, nervousness

Postmarketing reports: Tremor, dizziness, headache


Common (1% to 10%): Asthma, cough, increased sputum

Postmarketing reports: Tachypnea, bronchospasm, wheezing, tracheal edema, dyspnea


Common (1% to 10%): Back pain, myalgia

Postmarketing reports: Musculoskeletal chest pain, chills


Common (1% to 10%): Nausea, anorexia, circumoral paresthesia

Postmarketing reports: Tongue swelling, lip swelling


Common (1% to 10%): Chest pain, wound infection, chills

Postmarketing reports: Failure to achieve initial control, recurrent swelling refractory to treatment, prolonged hospitalization, treatment failure resulting in death, chest discomfort, swelling


Common (1% to 10%): Nervousness


Postmarketing reports: Worsening eye sight

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Crofab