Note: This document contains side effect information about cobimetinib. Some of the dosage forms listed on this page may not apply to the brand name Cotellic.
Common side effects of Cotellic include: skin photosensitivity. Other side effects include: increased creatine phosphokinase in blood specimen. See below for a comprehensive list of adverse effects.
Applies to cobimetinib: oral tablet
Along with its needed effects, cobimetinib (the active ingredient contained in Cotellic) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking cobimetinib:
Some side effects of cobimetinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Applies to cobimetinib: oral tablet
The most commonly reported adverse reactions (more than 35%) were increased creatinine, increased CPK, lymphopenia, increased AST, increased alkaline phosphatase, increased ALT, hypophosphatemia, anemia, increased gamma-glutamyltransferase, diarrhea, photosensitivity reactions, hypoalbuminemia, nausea, and hyponatremia.
Very common (10% or more): Increased creatinine (99.6%) Common (1% to 10%)
Very common (10% or more): Increased CPK (79%)
Very common (10% or more): Increased AST (73%), increased alkaline phosphatase (71%), increased ALT (68%), increased gamma-glutamyltransferase (65%)
Frequency not reported: Increased total bilirubin
Very common (10% or more): Lymphopenia (73%), anemia (69%), thrombocytopenia (18%), hemorrhage (e.g., rectal, hemorrhoidal, GI tract, uterine, vaginal, pulmonary, cerebral, subarachnoid, ocular, eye, conjunctival, retinal, reproductive system, melena, hematemesis, hematochezia, gingival bleeding, metrorrhagia, hemorrhagic ovarian cyst, menometrorrhagia, menorrhagia, hemoptysis, subgaleal hematoma, hematuria, epistaxis, contusion, traumatic hematoma, ecchymosis, purpura, nail bed bleeding)
Very common (10% or more): Dehydration, hypophosphatemia (68%), hypoalbuminemia (42%), hyponatremia (38%), hyperkalemia (26%), hypokalemia (25%), hypocalcemia (24%)
Very common (10% or more): Diarrhea (60%), nausea (41%), vomiting (24%), stomatitis (14%)
Very common (10% or more): Photosensitivity reactions (46%), acneiform dermatitis (16%), alopecia (15%), hyperkeratosis (11%), erythema (10%), maculopapular rash, dermatitis acneiform rash
Very common (10% or more): Pyrexia (28%), hemorrhage (13%), chills (10%) Common (1% to 10%):
Very common (10% or more): Decreased LVEF (26%), hypertension (15%)
Very common (10% or more): Vision impaired (e.g., vision blurred, visual acuity reduced, visual impairment) (15%), chorioretinopathy (e.g., retinal detachment, detachment of retinal pigment epithelium, detachment of macular retinal pigment epithelium) (13%), retinal detachment (e.g., retinal detachment, detachment of retinal pigment epithelium, detachment of macular retinal pigment epithelium) (12%)
Common (1% to 10%): Serious retinopathy (chorioretinopathy, retinal detachment)
Frequency not reported: Retinal vein occlusion
Common (1% to 10%): Cutaneous squamous cell carcinoma/keratoacanthoma, basal cell carcinoma
Uncommon (0.1% to 1%): Second primary melanoma, non-cutaneous malignancies
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Cotellic