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Corifact

Generic Name: factor XIII (FAK tor 13 (thirteen))
Brand Names: Corifact, Tretten
Corifact (Factor XIII) is used to prevent bleeding episodes is patients with congenital Factor XIII deficiency. Includes Corifact side effects, interactions and indications.
  • Prescription Settings

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Drug Information:
Corifact (factor XIII) is used to prevent bleeding episodes in people with a hereditary bleeding disorder caused by a deficiency of Factor XIII. Factor XIII (thirteen) is a naturally occurring protein in the blood that helps blood to clot. A lack of clotting factors can cause uncontrolled bleeding, as the blood is unable to clot properly. This medicine works by temporarily raising levels of these factor XIII in the blood to aid in clotting. Corifact will not treat a bleeding episode that has already begun. Learn more

Corifact Side Effects

Corifact Side Effects

Note: This document contains side effect information about factor XIII. Some of the dosage forms listed on this page may not apply to the brand name Corifact.

For the Consumer

Applies to factor XIII: intravenous powder for solution

Along with its needed effects, factor XIII (the active ingredient contained in Corifact) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking factor XIII:

More common

  • Bloody nose
  • bruise
  • collection of blood under the skin
  • deep, dark purple bruise
  • fever
  • itching, pain, redness, or swelling

Incidence not known

  • Chest pain
  • cough
  • dizziness or fainting
  • hives
  • pain in the chest, groin, or legs, especially the calves
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red, scaly, swollen, or peeling areas of the skin
  • severe, sudden headache
  • shortness of breath
  • tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over the affected area
  • unusual tiredness or weakness

Some side effects of factor XIII may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Difficulty with moving
  • general feeling of discomfort or illness
  • headache
  • joint pain
  • muscle aches and pains

For Healthcare Professionals

Applies to factor XIII: intravenous powder for injection

Hypersensitivity

Hypersensitivity side effects have included allergy, rash, pruritus, and erythema, chills/rise in temperature, arthralgia, headache, elevated thrombin antithrombin levels, and an increase in hepatic enzymes.

Hematologic

Hematologic side effects have included factor XIII (the active ingredient contained in Corifact) inhibitor formation.

Cardiovascular

Cardiovascular side effects have included thrombosis and embolism.

General

General side effects have included flu-like syndrome and pyrexia.

Gastrointestinal

Gastrointestinal side effects have included abdominal pain, diarrhea and vomiting.

Musculoskeletal

Musculoskeletal side effects have included contusion, joint injury, limb injury, road traffic accident, and arthralgia.

Respiratory

Respiratory side effects have included upper respiratory tract infection and epistaxis.

Nervous system

Nervous system side effects have included headache and head injury.

Immunologic

Immunologic side effects have included allergic/anaphylactic reaction (including cutaneous reactions, alteration in blood pressure, nausea, dyspnea, fever, and chills).

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Corifact