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Generic Name: brimonidine and timolol ophthalmic (bri MOE ni deen and TIM oh lol off THAL mik)
Brand Names: Combigan
Combigan (brimonidine and timolol) is used to treat glaucoma or ocular hypertension. Includes Combigan side effects, interactions and indications.
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Drug Information:
Combigan contains a combination of brimonidine and timolol. Timolol is a beta-blocker that also reduces pressure inside the eye. Combigan eye drops are used to treat open-angle glaucoma or ocular hypertension (high pressure inside the eye). Combigan may also be used for purposes not listed in this medication guide. You should not use Combigan eye drops if you have a history of asthma or chronic obstructive pulmonary disease (COPD), or a serious heart condition such as "AV block," severe heart failure, or slow heartbeats that have caused you to faint. Learn more

Combigan Side Effects

Combigan Side Effects

Note: This document contains side effect information about brimonidine / timolol ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Combigan.

For the Consumer

Applies to brimonidine/timolol ophthalmic: ophthalmic solution

Along with its needed effects, brimonidine/timolol ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking brimonidine/timolol ophthalmic:

More common

  • Burning, dry, or itching eyes
  • discharge or excessive tearing
  • redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid
  • stinging in the eyes
  • tiny bumps on lining of the eyelid

Less common

  • Blurred or loss of vision
  • disturbed color perception
  • dizziness
  • double vision
  • feeling of having something in the eye
  • halos around lights
  • headache
  • nervousness
  • night blindness
  • pounding in the ears
  • sensitivity of the eyes to light
  • slow, fast, or irregular heartbeat
  • tunnel vision
  • watery eyes

Get emergency help immediately if any of the following symptoms of overdose occur while taking brimonidine / timolol ophthalmic:

Symptoms of overdose

  • Chest pain or discomfort
  • cough
  • difficulty breathing
  • lightheadedness, dizziness or fainting
  • no blood pressure or pulse
  • noisy breathing
  • stopping of heart
  • tightness in the chest
  • unconsciousness

Some side effects of brimonidine / timolol ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Dry mouth
  • feeling sad or empty
  • irritability
  • lack of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • sleepiness or unusual drowsiness
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to brimonidine / timolol ophthalmic: ophthalmic solution


Very common (10% or more): Conjunctival hyperemia, burning sensation

Common (1% to 10%): Stinging sensation in the eye, allergic conjunctivitis, corneal erosion, superficial punctuate keratitis, eye pruritus, conjunctival folliculosis, visual disturbance, blepharitis, epiphora, eye dryness, eye discharge, eye pain, eye irritation, foreign body sensation, eyelid edema, eyelid pruritus, eyelid erythema

Uncommon (0.1% to 1%): Worsened visual acuity, conjunctival edema, conjunctivitis, vitreous floater, asthenopia, photophobia, papillary hypertrophy, eyelid pain, conjunctival blanching, corneal edema, corneal infiltrates, vitreous detachment, allergic contact dermatitis

Postmarketing reports: Blurred vision, keratoconjunctivitis sicca


-Frequency not reported: Iritis, iridocyclitis (anterior uveitis), miosis, cataract, conjunctival blanching, hordeolum, lid crusting, lid disorder


-Rare (less than 0.1%): Corneal calcification (with the use of phosphate containing eye drops in some patients with significantly damaged corneas)

-Frequency not reported: Keratitis, choroidal detachment following filtration surgery, decreased corneal sensitivity, corneal erosion, ptosis, diplopia, cystoid macular edema, pseudopemphigoid, refractive changes, blepharoptosis


Common (1% to 10%): Hypertension

Uncommon (0.1% to 1%): Congestive heart failure, palpitations

Postmarketing reports: Arrhythmia, bradycardia, tachycardia, hypotension, pallor


-Frequency not reported: Vasodilation


-Frequency not reported: Chest pain, atrioventricular block, cardiac arrest, cardiac failure, Raynaud's phenomenon, cold hands and feet, claudication, worsening of angina pectoris


Common (1% to 10%): Oral dryness

Uncommon (0.1% to 1%): Nausea, diarrhea


-Frequency not reported: Gastrointestinal symptoms


-Frequency not reported: Dyspepsia, abdominal pain, vomiting



-Frequency not reported: Systemic allergic reactions, systemic lupus erythematosus, flu syndrome


-Frequency not reported: Systemic allergic reactions including angioedema, urticaria, localized and generalized rash, pruritus, anaphylactic reaction

Nervous system

Common (1% to 10%): Somnolence, headache

Uncommon (0.1% to 1%): Dizziness, syncope, taste perversion

Postmarketing reports: Coma, lethargy


-Frequency not reported: Cerebrovascular accident, cerebral ischemia, increases in signs and symptoms of myasthenia gravis, paresthesia, disorientation, memory loss, tinnitus


Common (1% to 10%): Depression


-Frequency not reported: Insomnia


-Frequency not reported: Insomnia, nightmare, behavioral changes and psychic disturbances including confusion, hallucination


Uncommon (0.1% to 1%): Rhinitis, nasal dryness

Postmarketing reports: Respiratory depression


-Frequency not reported: Upper respiratory symptoms, dyspnea, apnea


-Frequency not reported: Bronchospasm (predominantly in patients with pre-existing bronchospastic disease), dyspnea, cough, upper respiratory infection, nasal congestion



-Frequency not reported: Sexual dysfunction, decreased libido, Peyronie's disease, retroperitoneal fibrosis


The commonly reported side effects were allergic conjunctivitis, conjunctival folliculosis, conjunctival hyperemia, eye pruritus, ocular burning, and stinging.


Postmarketing reports: Hypotonia


-Frequency not reported: Myalgia


Common (1% to 10%): Asthenic conditions

Postmarketing reports: Facial erythema


-Frequency not reported: Edema, fatigue



-Frequency not reported: Skin reaction including erythema, pruritus, rash


-Frequency not reported: Alopecia, psoriasiform rash or exacerbation of psoriasis, rash


Common (1% to 10%): Abnormal Liver Function Tests



-Frequency not reported: Masked symptoms of hypoglycemia in diabetes patients, hypercholesterolemia


-Frequency not reported: Hypoglycemia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Combigan