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Generic Name: clevidipine (kle VID a peen)
Brand Names: Cleviprex
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Drug Information:
Cleviprex (clevidipine) belongs to a group of drugs called calcium channel blockers. It works by relaxing the muscles of your heart and blood vessels. Cleviprex is used to treat high blood pressure (hypertension) in people who cannot take medicine by mouth. Cleviprex may also be used for purposes not listed in this medication guide. If possible before you receive Cleviprex, tell your doctor if you have high cholesterol or triglycerides (especially if you also have pancreatitis), aortic stenosis (narrowing of aortic valves in the heart), lipoid nephrosis (a kidney disorder), or if you are allergic to eggs or soy products. Learn more

Cleviprex Side Effects

Cleviprex Side Effects

Note: This document contains side effect information about clevidipine. Some of the dosage forms listed on this page may not apply to the brand name Cleviprex.

For the Consumer

Applies to clevidipine: intravenous emulsion

Along with its needed effects, clevidipine (the active ingredient contained in Cleviprex) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking clevidipine:

More common

  • Agitation
  • confusion
  • decreased urine output
  • depression
  • dizziness
  • fainting
  • fast or irregular heartbeat
  • headache
  • hostility
  • irritability
  • lethargy
  • loss of consciousness
  • muscle twitching
  • nausea
  • rapid weight gain
  • seizures (convulsions)
  • stupor
  • swelling of the face, ankles, or hands
  • unusual tiredness or weakness


  • Chest pain or discomfort
  • difficult or labored breathing
  • pain or discomfort in the arms, jaw, back, or neck
  • shortness of breath
  • stopping of the heart
  • sweating
  • tightness in the chest
  • unconsciousness
  • very low blood pressure or pulse
  • vomiting
  • wheezing

For Healthcare Professionals

Applies to clevidipine: intravenous emulsion


Atrial fibrillation, sinus tachycardia, and hypotension were frequently observed in the perioperative population.


Very common (10% or more): Atrial fibrillation (up to 32.9%), sinus tachycardia (up to 30.5%), hypotension (up to 15.1%)

Common (1% to 10%): Flushing

Uncommon (0.1% to 1%): Atrial flutter, tachycardia, congestive heart failure, bradycardia, complete atrioventricular block, bundle branch block

Frequency not reported: Myocardial infarction, cardiac arrest

Postmarketing reports: Reflex tachycardia


Very common (10% or more): Nausea (up to 21%)

Common (1% to 10%): Vomiting

Uncommon (0.1% to 1%): Constipation

Rare (less than 0.1%): Ileus

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Frequency not reported: Syncope


Common (1% to 10%): Edema, chest pain, feeling hot


Common (1% to 10%): Oxygen saturation decreased

Postmarketing reports: Blood triglycerides increased


Common (1% to 10%): Acute renal failure


Common (1% to 10%): Polyuria


Uncommon (0.1% to 1%): Pulmonary congestion

Frequency not reported: Dyspnea


Uncommon (0.1% to 1%): Hypersensitivity

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cleviprex