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Clarinex-d 12 hour

Generic Name: desloratadine and pseudoephedrine (DES loe RAT a deen and SOO doe ee FED rin)
Brand Names: Clarinex-D 12 Hour, Clarinex-D 24 Hour
Clarinex-D 12 Hour is used to treat sneezing, cough, runny nose, itchy eyes, hives, itching, and other symptoms of allergies and colds. Includes Clarinex-D 12 Hour side effects, interactions and indications.
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Drug Information:
Clarinex-D 12 Hour contains a combination of desloratadine and pseudoephedrine. Desloratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Clarinex-D 12 Hour is used to treat sneezing, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold. Learn more

Clarinex-d 12 hour Side Effects

Clarinex-D 12 Hour Side Effects

Note: This document contains side effect information about desloratadine / pseudoephedrine. Some of the dosage forms listed on this page may not apply to the brand name Clarinex-D 12 Hour.

In Summary

More frequent side effects include: headache, insomnia, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to desloratadine/pseudoephedrine: oral tablet extended release 12 hr, oral tablet extended release 24 hr

Along with its needed effects, desloratadine / pseudoephedrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking desloratadine / pseudoephedrine:

Observed during clinical practice

  • Abdominal or stomach pain area
  • chills
  • clay-colored stools
  • cough
  • dark urine
  • difficult or labored breathing
  • difficulty swallowing
  • dizziness
  • elevated liver enzymes
  • fast heartbeat
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • general tiredness and weakness
  • headache
  • hives
  • irregular heartbeat
  • itching
  • light-colored stools
  • loss of appetite
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • rash
  • redness of skin
  • shortness of breath
  • skin rash
  • swelling
  • tightness in chest
  • unpleasant breath odor
  • unusual tiredness or weakness
  • upper right abdominal pain
  • vomiting of blood
  • vomiting
  • welts
  • wheezing
  • yellow eyes or skin

Symptoms of overdose

Get emergency help immediately if any of the following symptoms of overdose occur while taking desloratadine / pseudoephedrine:

  • Increased heart rate
  • sleepiness or unusual drowsiness

Some side effects of desloratadine / pseudoephedrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Dry mouth
  • sleeplessness
  • trouble sleeping
  • unable to sleep

Less common

  • Body aches or pain
  • congestion
  • dryness or soreness of throat
  • hoarseness
  • nervousness
  • restlessness
  • runny nose
  • sleepiness or unusual drowsiness
  • tender, swollen glands in neck
  • trouble sitting still
  • voice changes
  • weight loss

For Healthcare Professionals

Applies to desloratadine / pseudoephedrine: oral tablet extended release


Very common (10% or more): Insomnia (10%)


Frequency not reported: Arrhythmias, cardiovascular collapse with accompanying hypotension

Postmarketing reports: Tachycardia, palpitations


Frequency not reported: Hypersensitivity reactions (including rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis)

Nervous system

Common (1% to 10%): Headache, somnolence, dizziness

Frequency not reported: Insomnia, tremor, nervous system stimulation with convulsions


Common (1% to 10%): Mouth dry, nausea


Frequency not reported: Severe skin reactions

Postmarketing reports: Rash, pruritus


Common (1% to 10%): Anorexia


Frequency not reported: Narrow-angle glaucoma


Frequency not reported: Urinary retention in patients with prostatic hypertrophy


Common (1% to 10%): Pharyngitis

Postmarketing reports: Dyspnea


Frequency not reported: Weakness

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Clarinex-d 12 Hour