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Generic Name: chenodiol (chenodeoxycholic acid) (KEE noe DYE ol (KEE noe dee OX i KOL ik AS id))
Brand Name: Chenodal
Physician reviewed Chenodal patient information - includes Chenodal description, dosage and directions.
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Drug Information:
Chenodal is made from bile acid, a substance that occurs naturally in the body. Chenodal is used to dissolve gallstones in people who cannot have gallbladder surgery. Chenodal may also be used for purposes not listed in this medication guide. You should not use Chenodal if you have liver disease, cirrhosis, or certain conditions that cause an obstruction in your digestive system. Chenodal can harm an unborn baby or cause birth defects. Do not use if you are pregnant. You should not use Chenodal if you are allergic to it, or if: Learn more

Chenodal Side Effects

Chenodal Side Effects

Note: This document contains side effect information about chenodeoxycholic acid. Some of the dosage forms listed on this page may not apply to the brand name Chenodal.

In Summary

Common side effects of Chenodal include: increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to chenodeoxycholic acid: oral tablet

Along with its needed effects, chenodeoxycholic acid (the active ingredient contained in Chenodal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking chenodeoxycholic acid:

Incidence not known

  • Black, tarry stools
  • chest pain
  • chills
  • cough
  • fever
  • painful or difficult urination
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Some side effects of chenodeoxycholic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea

Less common

  • Abdominal or stomach pain
  • acid or sour stomach
  • belching
  • bloated
  • cramps
  • difficulty having a bowel movement (stool)
  • excess air or gas in the stomach or intestines
  • full feeling
  • heartburn
  • indigestion
  • loss of appetite
  • nausea and vomiting
  • pain in the chest below the breastbone
  • pain or discomfort in chest, upper stomach, or throat
  • passing gas
  • stomach discomfort or upset
  • weight loss

For Healthcare Professionals

Applies to chenodeoxycholic acid: oral tablet


Frequency not reported: Constipation/mild intermittent constipation, cramps, diarrhea, dyspepsia, epigastric distress, flatulence, gastrostomy, heartburn, nausea, nonspecific abdominal pain, urgency, vomiting


Frequency not reported: ALT elevations, biliary colic, cholecystectomy, hepatic adverse reactions, intrahepatic cholestasis, lithiasis, lithocholate-like lesions in the canalicular membrane, serum transaminase elevations, toxic hepatitis


Serum total cholesterol and LDL cholesterol may increase by at least 10%.

Small decreases in serum triglycerides occurred in female patients.

Frequency not reported: Anorexic, increased serum low density lipoprotein (LDL) cholesterol, increased serum total cholesterol, small decreases in serum triglyceride levels


Frequency not reported: Humerus fracture, foot operation, rheumatoid arthritis


Frequency not reported: Angina pectoris


Frequency not reported: Pneumothorax


Frequency not reported: Decreases in while cell count


Frequency not reported: Urinary incontinence


Frequency not reported: Cataract operation


Frequency not reported: Fatigue


Frequency not reported: Depression

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Chenodal