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Generic Name: imiglucerase (im ih GLUE ker ase)
Brand Names: Cerezyme
Cerezyme is used for the treatment of Type 1 Gaucher disease. Learn about side effects, interactions and indications.
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Drug Information:
Cerezyme (imiglucerase) is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in people with Type I Gaucher disease. Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured. Cerezyme may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease. However, this medicine is not a cure for this condition. Learn more

Cerezyme Side Effects

Cerezyme Side Effects

Note: This document contains side effect information about imiglucerase. Some of the dosage forms listed on this page may not apply to the brand name Cerezyme.

For the Consumer

Applies to imiglucerase: intravenous powder for solution

Along with its needed effects, imiglucerase (the active ingredient contained in Cerezyme) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects of imiglucerase may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Abdominal discomfort
  • decrease in blood pressure, decrease in frequency of urination
  • dizziness
  • headache
  • itching
  • nausea
  • rash

For Healthcare Professionals

Applies to imiglucerase: intravenous powder for injection


Experience in patients treated with this drug have revealed that about 13.8% of patients experienced adverse events which were judged to be related to administration and included discomfort, pruritus, burning, swelling, or sterile abscess at the site of venipuncture.


Common (1% to 10%): Discomfort, burning, swelling, sterile abscess

Frequency not reported: Pruritus


Common (1% to 10%): Nausea, abdominal pain, vomiting, diarrhea

Uncommon (0.1% to 1%): Abdominal cramping


Common (1% to 10%): Tachycardia

Uncommon (0.1% to 1%): Flushing, hypotension, cyanosis


Common (1% to 10%): Hypersensitivity reaction

Rare (less than 0.1%): Anaphylactoid reaction


Common (1% to 10%): Rash, urticaria, pruritus, angioedema


Common (1% to 10%): Backache

Uncommon (0.1% to 1%): Arthralgia


Common (1% to 10%): Dyspnea, coughing

Nervous system

Common (1% to 10%): Headache, dizziness

Uncommon (0.1% to 1%): Paresthesia


Common (1% to 10%): Fatigue, fever, chills

Uncommon (0.1% to 1%): Rigors

Frequency not reported: Chest discomfort, peripheral edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cerezyme