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Generic Name: methsuximide (meth SUX i mide)
Brand Name: Celontin
Physician reviewed Celontin patient information - includes Celontin description, dosage and directions.
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Drug Information:
Celontin is an anti-epileptic medication, also called an anticonvulsant. Celontin is used alone or in combination with other medications to treat absence seizures (also called "petit mal" seizures) in adults and children. Celontin may also be used for purposes not listed in this medication guide. Serious and sometimes fatal infections may occur during treatment with Celontin. Call your doctor right away if you have signs of infection such as: fever, swollen glands, sore throat, easy bruising, unusual bleeding (nose, mouth), feeling very weak or tired. Learn more

Celontin Side Effects

Celontin Side Effects

Note: This document contains side effect information about methsuximide. Some of the dosage forms listed on this page may not apply to the brand name Celontin.

For the Consumer

Applies to methsuximide: oral capsule

Along with its needed effects, methsuximide (the active ingredient contained in Celontin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking methsuximide:


  • Attempts at killing oneself
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • severe mood or mental changes
  • unusual behavior

Incidence not known

  • Attack, assault, or force
  • blistering, peeling, or loosening of the skin
  • blood in the urine
  • bloody, black, or tarry stools
  • chest pain
  • chills
  • cloudy urine
  • cough or hoarseness
  • diarrhea
  • discouragement
  • feeling sad or empty
  • fever
  • high fever
  • irritability
  • itching
  • joint or muscle pain
  • lack of appetite
  • loss of interest or pleasure
  • lower back or side pain
  • mood or mental changes
  • nervousness
  • painful or difficult urination
  • pale skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • shakiness and unsteady walk
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling around the eyes
  • swollen glands
  • tiredness
  • trouble with concentrating
  • trouble with sleeping
  • unexplained bleeding or bruising
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vision changes

Get emergency help immediately if any of the following symptoms of overdose occur while taking methsuximide:

Symptoms of overdose

  • Change in consciousness
  • difficult or troubled breathing
  • irregular, fast or slow, or shallow breathing
  • loss of consciousness
  • pale or blue lips, fingernails, or skin

Some side effects of methsuximide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Blurred vision
  • change in color vision
  • difficulty having a bowel movement (stool)
  • difficulty seeing at night
  • dizziness
  • drowsiness
  • heartburn
  • hiccups
  • hives or welts
  • increased sensitivity of the eyes to sunlight
  • loss of appetite
  • nausea or vomiting
  • pain or discomfort in the chest, upper stomach, or throat
  • redness of the skin
  • skin rash
  • sleeplessness
  • unable to sleep
  • weight loss

For Healthcare Professionals

Applies to methsuximide: oral capsule


The more frequently reported adverse events have included gastrointestinal symptoms such as nausea, vomiting, and anorexia and neurologic reactions such as drowsiness, dizziness and headache.


Frequency not reported: Nausea, vomiting, anorexia, diarrhea, weight loss, epigastric and abdominal pain, constipation, hiccups

Nervous system

Frequency not reported: Drowsiness, ataxia, dizziness, headache


Rare (less than 0.1%): Psychosis, suicidal behavior, auditory hallucinations

Frequency not reported: Confusion, instability, mental slowness, depression, hypochondriacal behavior, aggressiveness, irritability, nervousness, insomnia.


Frequency not reported: Eosinophilia, leukopenia, monocytosis, and pancytopenia with or without bone marrow suppression


Frequency not reported: Periorbital edema, blurred vision


Frequency not reported: Proteinuria, microscopic hematuria


Frequency not reported: Hyperemia


Frequency not reported: Urticaria, Stevens-Johnson syndrome, pruritic erythematous rashes

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Celontin