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Cellcept intravenous

Generic Name: mycophenolate mofetil (oral/injection) (MYE koe FEN oh late MOE fe til)
Brand Names: CellCept, Myfortic, MMF
Cellcept (mycophenolate mofetil) is used to prevent rejection of a kidney, liver, or heart transplant. Includes Cellcept side effects, interactions and indications.
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Drug Information:
CellCept (mycophenolate mofetil) weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it. CellCept is used with other medicines to prevent organ rejection after a kidney, liver, or heart transplant. CellCept is usually given with cyclosporine (Sandimmune, Neoral) and a steroid medication. It can be given by mouth or as an injection. CellCept can cause a miscarriage or birth defects when used during pregnancy. Women using mycophenolate mofetil should use effective birth control to prevent pregnancy. However, if no safer options are available, CellCept is sometimes given to pregnant women. Learn more

Cellcept intravenous Side Effects

CellCept Side Effects

Note: This document contains side effect information about mycophenolate mofetil. Some of the dosage forms listed on this page may not apply to the brand name CellCept.

In Summary

Common side effects of CellCept include: asthma, herpes simplex infection, infection, metabolic acidosis, oral candidiasis, pleural effusion, respiratory tract infection, systemic cytomegalovirus disease, urinary tract infection, viremia, abdominal pain, acne vulgaris, anemia, anxiety, asthenia, back pain, cardiovascular disorder, chest pain, constipation, cough, depression, diarrhea, disorder of integument, drowsiness, dyspepsia, dyspnea, edema, fever, headache, hypercholesterolemia, hyperlipidemia, hypertension, hypertonia, hyperuricemia, hypervolemia, hypokalemia, hypotension, increased lactate dehydrogenase, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, increased serum creatinine, leukopenia, lower limb cramp, myalgia, myasthenia, nausea, pain, paresthesia, peripheral edema, pulmonary disease, rhinitis, sinusitis, tachycardia, thrombocytopenia, tremor, vomiting, weight gain, chills, and flatulence. Other side effects include: malignant neoplasm of skin, dizziness, and insomnia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to mycophenolate mofetil: oral capsule, oral powder for suspension, oral tablet

Other dosage forms:

  • intravenous powder for solution

Warning

Oral route (Capsule; Tablet; Powder for Suspension)

Provide information on pregnancy prevention and planning to female patients of childbearing potential, as this drug is associated with increased risk of first-trimester pregnancy loss and congenital malformations. In addition, use may increase susceptibility to infection. Lymphoma may develop as a result of immunosuppression. Only physicians experienced in immunosuppressive therapy and management of organ transplant recipients should prescribe this drug, and they should have complete information needed for patient followup.

Along with its needed effects, mycophenolate mofetil (the active ingredient contained in CellCept) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking mycophenolate mofetil:

More common

  • Abdominal or stomach cramps or pain
  • black, tarry stools
  • bladder pain
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • bloody or cloudy urine
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • confusion
  • convulsions
  • cough or hoarseness
  • decreased urine
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • drowsiness
  • dry mouth
  • fainting
  • fast, slow, pounding, or irregular heartbeat or pulse
  • fever or chills
  • flushed, dry skin
  • frequent urge to urinate
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • irregular heartbeats
  • irregular pulse
  • irritability
  • lightheadedness
  • loss of appetite
  • lower back or side pain
  • muscle cramps in the hands, arms, feet, legs, or face
  • muscle pain or cramps
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • pounding in the ears
  • rapid weight gain
  • rapid, shallow breathing
  • seizures
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stomach pain and bloating
  • sweating
  • swollen glands
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • tremor
  • troubled breathing with exertion
  • unexplained weight loss
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness or heaviness of the legs

Incidence not known

  • Back pain
  • constipation
  • coughing or spitting up blood
  • darkened urine
  • general feeling of illness
  • indigestion
  • night sweats
  • pain
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • severe headache
  • sudden high fever or low-grade fever for months
  • tenderness
  • watery or bloody diarrhea
  • yellow eyes or skin

Some side effects of mycophenolate mofetil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • fear
  • heartburn
  • lack or loss of strength
  • rash
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to mycophenolate mofetil: intravenous powder for injection, oral capsule, oral powder for reconstitution, oral tablet

Gastrointestinal

Very common (10% or more): Diarrhea (36%), nausea (20%), vomiting (13%), abdominal pain

Common (1% to 10%): GI infection, gastroenteritis

Rare (less than 0.1%): Gingival hyperplasia, colitis including cytomegalovirus colitis, pancreatitis intestinal villous atrophy

Frequency not reported: Ischemic colitis

Hematologic

Very common (10% or more): Leukopenia (11% to 35%), anemia (35%)

Common (1% to 10%): Blood creatinine increased, blood lactate dehydrogenase increased, blood urea increased, blood alkaline phosphatase increased, thrombocytopenia, neutropenia

Very rare (less than 0.01%): Deep venous thrombosis

Postmarketing reports: Pure red cell aplasia (PRCA), abnormal neutrophil morphology, including the acquired Pelger-Huet anomaly

Immunologic

Very common (10% or more): Sepsis (primarily cytomegalovirus viremia) (20%), gastrointestinal candidiasis, urinary tract infection, herpes simplex, herpes zoster

Common (1% to 10%): Pneumonia, influenza, respiratory tract infection, respiratory moniliasis, gastrointestinal infection, candidiasis, gastroenteritis, infection, bronchitis, pharyngitis, sinusitis, fungal skin infection, skin candida, vaginal candidiasis

Postmarketing reports: Hypogammaglobulinemia Serious life-threatening infections including meningitis, endocarditis, tuberculosis, atypical mycobacterial infection

Oncologic

Common (1% to 10%): Lymphoma, lymphoproliferative disease, non-melanoma skin carcinoma

Renal

Very common (10% or more): Hematuria (13%), kidney tubular necrosis (up to 10%)

Common (1% to 10%): Renal impairment

Frequency not reported: BK virus-associated nephropathy

Metabolic

Very common (10% or more): Edema (12% to 28%), hyperphosphatemia (13%), hypokalemia (10%), hyperglycemia (10%)

Common (1% to 10%): Weight loss, hyperkalemia

Respiratory

Very common (10% or more): Respiratory tract infection (23%), dyspnea (16%), increased cough (16%)

Common (1% to 10%): Pneumonia, respiratory moniliasis, bronchitis, pharyngitis, sinusitis, rhinitis, pleural effusion

Dermatologic

Common (1% to 10%): Fungal skin infection, skin hypertrophy, rash, acne, alopecia

Very rare (less than 0.01%): Dyshidrotic eczema, papulosquamous psoriatic-like skin eruption

Musculoskeletal

Common (1% to 10%): Arthralgia

Very rare (less than 0.01%): Myopathy

Other

Common (1% to 10%): Edema, pyrexia, chills, pain, malaise, asthenia

Frequency not reported: Congenital malformations, increased incidence of first trimester pregnancy loss

Hepatic

Common (1% to 10%): Hepatitis, jaundice, hyperbilirubinemia, hepatic enzyme increased

Very rare (less than 0.01%): Sodium-induced hepatotoxicity

Cardiovascular

Common (1% to 10%): Tachycardia, hypotension, hypertension, vasodilatation

Postmarketing reports: Endocarditis

Genitourinary

Common (1% to 10%): Urinary tract infection (up to 45%), vaginal candidiasis

Hypersensitivity

Postmarketing reports: Angioneurotic edema, anaphylactic reaction

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cellcept Intravenous