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Generic Name: carglumic acid (kar GLOO mik AS id)
Brand Names: Carbaglu
Carbaglu (carglumic acid) is used to treat hyperammonemia, a urea cycle disorder caused by lack of a certain liver enzyme. Includes Carbaglu side effects, interactions and indications.
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Drug Information:
Carbaglu (carglumic acid) is a man-made form of an enzyme that occurs naturally in the liver. This enzyme is necessary for processing excess nitrogen produced when the body metabolizes proteins. Without this enzyme, nitrogen builds up in the form of ammonia and is not removed from the body. Ammonia is very toxic when it circulates in blood and tissues and can cause permanent brain damage, coma, or death. Carbaglu is used to treat hyperammonemia (HYE-per-AM-moe-NEE-mee-a), a urea cycle disorder caused by lack of a certain liver enzyme. Learn more

Carbaglu Side Effects

Carbaglu Side Effects

Note: This document contains side effect information about carglumic acid. Some of the dosage forms listed on this page may not apply to the brand name Carbaglu.

For the Consumer

Applies to carglumic acid: oral tablet

Along with its needed effects, carglumic acid (the active ingredient contained in Carbaglu) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking carglumic acid:

More common

  • Chills
  • cough
  • decreased weight
  • diarrhea
  • fever
  • general feeling of discomfort or illness
  • headache
  • hoarseness
  • increased sweating
  • joint pain
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • nausea
  • painful or difficult urination
  • pale skin
  • runny nose
  • shivering
  • sore throat
  • sweating
  • trouble sleeping
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Get emergency help immediately if any of the following symptoms of overdose occur while taking carglumic acid:

Symptoms of overdose

  • Fast, pounding, or irregular heartbeat or pulse
  • increase in mucous from the lungs
  • restlessness

Some side effects of carglumic acid may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Change in hearing
  • change in taste
  • congestion
  • ear drainage
  • earache or pain in the ear
  • lack or loss of strength
  • loss of taste
  • rash
  • sleepiness or unusual drowsiness
  • stomach pain
  • stuffy or runny nose
  • swollen glands

For Healthcare Professionals

Applies to carglumic acid: oral tablet dispersible


The more commonly reported adverse reactions have included vomiting, abdominal pain, pyrexia, and infection.


Very common (10% or more): Vomiting (26%), abdominal pain (17%), tonsillitis (17%), diarrhea (13%)

Common (1% to 10%): Dysgeusia


Common (1% to 10%): Decreased weight, anorexia, hyperglycemia


Very common (10% or more): Infections (13%)

Common (1% to 10%): Influenza


Very common (10% or more): Anemia (13%), decreased hemoglobin (13%)

Common (1% to 10%): Thrombocytopenia

Nervous system

Very common (10% or more): Headache (13%)

Common (1% to 10%): Somnolence


Common (1% to 10%): Hyperhidrosis, rash


Common (1% to 10%): Increased transaminases


Very common (10% or more): Nasopharyngitis (13%)

Common (1% to 10%): Pneumonia, oxygen saturation decreased


Very common (10% or more): Pyrexia (17%), ear infection (13%)

Common (1% to 10%): Asthenia


Common (1% to 10%): Cardiac murmur

Uncommon (0.1% to 1%): Bradycardia

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Carbaglu