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Generic Name: sucralfate (oral) (soo KRAL fate)
Brand Names: Carafate
Carafate is an anti-ulcer medication used to treat active duodenal ulcers. Learn about side effects, interactions and indications.
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Drug Information:
Carafate (sucralfate) is an anti-ulcer medication. Carafate is not greatly absorbed into the body through the digestive tract. It works mainly in the lining of the stomach by sticking to ulcer sites and protecting them from acids, enzymes, and bile salts. Carafate is used to treat an active duodenal ulcer. Sucralfate can heal an active ulcer, but it will not prevent future ulcers from occurring. The liquid form of Carafate should never be injected through a needle into the body, or death may occur. Learn more

Carafate Side Effects

Carafate Side Effects

Note: This document contains side effect information about sucralfate. Some of the dosage forms listed on this page may not apply to the brand name Carafate.

For the Consumer

Applies to sucralfate: oral suspension, oral tablet

Along with its needed effects, sucralfate (the active ingredient contained in Carafate) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sucralfate:

Incidence not known

  • Blue lips and fingernails
  • blurred vision
  • chest pain
  • cough
  • coughing that sometimes produces a pink frothy sputum
  • difficult, fast, noisy breathing
  • difficulty in swallowing
  • dry mouth
  • feeling of fullness
  • flushed, dry skin
  • fruit-like breath odor
  • hoarseness
  • increased hunger
  • increased sweating
  • increased thirst
  • increased urination
  • loss of appetite
  • nausea
  • pale skin
  • slow or irregular breathing
  • stomach pain
  • sweating
  • swelling of the face, mouth, lips, or throat
  • swelling of the legs and ankles
  • tightness in the chest
  • troubled breathing
  • unexplained weight loss
  • unusual tiredness or weakness
  • vomiting

Some side effects of sucralfate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Constipation


  • Back ache
  • bloated
  • constipation
  • diarrhea
  • dizziness or lightheadedness
  • excess air or gas in the stomach or intestines
  • feeling of constant movement of self or surroundings
  • headache
  • hives, itching, skin rash
  • indigestion
  • passing gas
  • sensation of spinning
  • sleepiness
  • stomach cramps
  • trouble sleeping

For Healthcare Professionals

Applies to sucralfate: compounding powder, oral suspension, oral tablet


The most commonly reported side effect was constipation.


Common (1% to 10%): Constipation

Uncommon (0.1% to 1%): Dry mouth, nausea

Rare (0.01% to 0.1%): Bezoar formation

Frequency not reported: Diarrhea, flatulence, gastric discomfort, indigestion, vomiting

Postmarketing reports: Lip swelling, mouth edema

Bezoars were reported in patients with enteral feedings, delayed gastric emptying, and/or low birthweight neonates.

Nervous system

Encephalopathy occurred in patients with chronic renal impairment and/or on long-term treatment.

Cerebral emboli occurred in patients receiving IV administration.

Common (1% to 10%): Headache

Frequency not reported: Dizziness, drowsiness/sleepiness, encephalopathy, vertigo

Postmarketing reports: Cerebral emboli


Uncommon (0.1% to 1%): Urticaria

Rare (0.01% to 0.1%): Rash

Frequency not reported: Pruritus

Postmarketing reports: Face edema


Osteodystrophy and osteomalacia occurred in patients with chronic renal impairment and/or on long-term treatment.

Frequency not reported: Back pain, osteodystrophy, osteomalacia


Frequency not reported: Anaphylactic reaction, hypersensitivity reactions


Pulmonary edema occurred after IV administration.

Frequency not reported: Dyspnea

Postmarketing reports: Bronchospasm, laryngeal edema, pharyngeal edema, pulmonary emboli, respiratory tract edema


Frequency not reported: Thirst

Postmarketing reports: Face edema


Anemia occurred in patients with chronic renal impairment and/or on long-term treatment.

Frequency not reported: Anemia


Frequency not reported: Insomnia


Frequency not reported: Hyperglycemia


Frequency not reported: Edema

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Carafate