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Generic Name: acalabrutinib (a KAL a BROO ti nib)
Brand Names: Calquence
Calquence (acalabrutinib) is used to treat mantle cell lymphoma and chronic lymphocytic leukemia. Includes Calquence side effects, interactions and indications.
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Drug Information:
Calquence (acalabrutinib) blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells. Calquence is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. This medicine is given after other treatments have failed. Calquence was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, patients responded to this medicine. However, further studies are needed. Calquence is also used to treat chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) in adults. Learn more

Calquence Side Effects

Calquence Side Effects

Note: This document contains side effect information about acalabrutinib. Some of the dosage forms listed on this page may not apply to the brand name Calquence.

For the Consumer

Applies to acalabrutinib: oral capsule

Along with its needed effects, acalabrutinib (the active ingredient contained in Calquence) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acalabrutinib:

More common

  • Bleeding gums
  • collection of blood under the skin
  • coughing up blood
  • difficulty in breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • itching, pain, redness, or swelling
  • large, flat, blue or purplish patches in the skin
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine

Some side effects of acalabrutinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Constipation
  • diarrhea
  • difficulty in moving
  • joint pain or swelling
  • muscle cramp, pain, or stiffness
  • nausea
  • rash
  • stomach pain
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to acalabrutinib: oral capsule


The most common adverse reactions (reported incidence of 20% or greater) were anemia, thrombocytopenia, headache, neutropenia, diarrhea, fatigue, myalgia, and bruising.


Very common (10% or more): Bleeding events (50%)

Common (1% to 10%): Hemorrhage/hematoma

Uncommon (0.1% to 1%): Atrial fibrillation, atrial flutter


Very common (10% or more): Decreased hemoglobin (46%), decreased platelets (44%), decreased neutrophils (36%), neutropenia (23%), anemia (11%)

Common (1% to 10%): Thrombocytopenia

Nervous system

Very common (10% or more): Headache (39%)


Very common (10% or more): Diarrhea (31%), nausea (19%), abdominal pain (15%), constipation (15%), vomiting (13%)


Very common (10% or more): Bruising/petechiae/ecchymosis/contusion (21%), rash (18%)


Very common (10% or more): Myalgia (21%)


Very common (10% or more): Second primary malignancies (11%)

Common (1% to 10%): Skin cancer


Common (1% to 10%): Increased creatinine


Common (1% to 10%): Epistaxis

Frequency not reported: Pneumonia


Very common (10% or more): Fatigue (28%)

Frequency not reported: Infections

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Calquence