Please wait...


Generic Name: Ergotamine and Caffeine Tablets (er GOT a meen & KAF een)
Brand Name: Cafergot
Easy-to-read patient leaflet for Cafergot (Ergotamine and Caffeine Tablets). Includes indications, proper use, special instructions, precautions, and possible side effects.
  • Prescription Settings

Prices and coupons of Cafergot

Current Location: 20149 (Ashburn)
Change Location?

Enter your zip code

Please wait while the prices are loaded...

Don’t see your pharmacy listed? Most pharmacies accept our discounts, so have your pharmacist enter this coupon to see if you will save money:

Drug Information:
This is not a list of all drugs or health problems that interact with Cafergot (ergotamine and caffeine tablets). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Cafergot (ergotamine and caffeine tablets) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. For all patients taking Cafergot (ergotamine and caffeine tablets): Learn more

Cafergot Side Effects

Cafergot Side Effects

Note: This document contains side effect information about caffeine / ergotamine. Some of the dosage forms listed on this page may not apply to the brand name Cafergot.

For the Consumer

Applies to caffeine / ergotamine: oral tablet

Other dosage forms:

  • rectal suppository


  • Poor blood flow to the hands, feet, or brain has happened when this drug was taken with certain other drugs like clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nelfinavir, ritonavir, and troleandomycin. This may be very bad or even deadly. Do not take this drug if you are taking any of these drugs. There are many drugs that can do this. Check to make sure that it is safe for you to take this drug with all of your drugs.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight.
  • Chest pain or pressure.
  • Slow heartbeat.
  • Swelling.
  • Dizziness or passing out.
  • Muscle pain or weakness.
  • Change in color of hands or feet from pale to blue or red.
  • Numbness, pain, tingling, or cold feeling of the hands or feet.
  • Any sores or wounds on the fingers or toes.
  • Rarely, heart valve problems have happened with this drug. Call your doctor right away if you have a fast or abnormal heartbeat, shortness of breath, swelling in the arms or legs, or a big weight gain.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Upset stomach or throwing up.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to caffeine / ergotamine: oral tablet, rectal suppository


The most commonly reported adverse effects have included nausea and vomiting.


Common (1% to 10%): Nausea, vomiting, abdominal pain

Uncommon (0.1% to 1%): Diarrhea

Frequency not reported: Retroperitoneal fibrosis

Nervous system

Common (1% to 10%): Dizziness

Uncommon (0.1% to 1%): Paraesthesia, hypoaesthesia

Rare (less than 0.1%): Cerebral ischemia, drowsiness

Frequency not reported: Weakness, somnolence, drug-induced headaches, withdrawal headaches

Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.

Drug-induced headaches have been reported during prolonged and uninterrupted use. Withdrawal headaches have been reported with discontinuation after prolonged use.


Uncommon (0.1% to 1%): Peripheral vasoconstriction

Rare (0.01% to 0.1%): Tachycardia, bradycardia, increased blood pressure

Very rare (less than 0.01%): Myocardial ischemia, myocardial infarction, gangrene

Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes

Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.


Rare (Less than 0.1%): Dyspnea

Frequency not reported: Pleuropulmonary fibrosis, fibrotic thickening of pulmonary valves


Uncommon (0.1% to 1%): Extremity pain

Rare (Less than 0.1%): Myalgia


Rare (less than 0.1%): Rash, face edema, urticaria


Frequency not reported: Visual impairment

Postmarketing reports: Loss of vision

Sudden and transient loss of vision have been reported, possibly due to vasospasm and ischemic episode.


Rare (less than 0.1%): Rectal or anal ulcer

Solitary rectal or anal ulcer have occurred, usually at higher than recommended doses or with continuous use for many years


Frequency not reported: Vertigo


Rare (Less than 0.1%): Rash, face edema, urticaria

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cafergot