Note: This document contains side effect information about caffeine / ergotamine. Some of the dosage forms listed on this page may not apply to the brand name Cafergot.
Applies to caffeine / ergotamine: oral tablet
Other dosage forms:
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Applies to caffeine / ergotamine: oral tablet, rectal suppository
The most commonly reported adverse effects have included nausea and vomiting.
Common (1% to 10%): Nausea, vomiting, abdominal pain
Uncommon (0.1% to 1%): Diarrhea
Frequency not reported: Retroperitoneal fibrosis
Common (1% to 10%): Dizziness
Uncommon (0.1% to 1%): Paraesthesia, hypoaesthesia
Rare (less than 0.1%): Cerebral ischemia, drowsiness
Frequency not reported: Weakness, somnolence, drug-induced headaches, withdrawal headaches
Reports of cerebral ischemia, including 1 death, have been reported for patients receiving ergotamine and protease inhibitors concomitantly. A black box warning is now required labeling for these drugs.
Drug-induced headaches have been reported during prolonged and uninterrupted use. Withdrawal headaches have been reported with discontinuation after prolonged use.
Uncommon (0.1% to 1%): Peripheral vasoconstriction
Rare (0.01% to 0.1%): Tachycardia, bradycardia, increased blood pressure
Very rare (less than 0.01%): Myocardial ischemia, myocardial infarction, gangrene
Frequency not reported: Ischemia, cyanosis, absence of pulse, cold extremities, precordial distress, EKG changes
Serious vasoconstrictive have occurred, more commonly with long-term therapy at relatively high doses, however, they have been reported with short-term or normal doses.
Rare (Less than 0.1%): Dyspnea
Frequency not reported: Pleuropulmonary fibrosis, fibrotic thickening of pulmonary valves
Uncommon (0.1% to 1%): Extremity pain
Rare (Less than 0.1%): Myalgia
Rare (less than 0.1%): Rash, face edema, urticaria
Frequency not reported: Visual impairment
Postmarketing reports: Loss of vision
Sudden and transient loss of vision have been reported, possibly due to vasospasm and ischemic episode.
Rare (less than 0.1%): Rectal or anal ulcer
Solitary rectal or anal ulcer have occurred, usually at higher than recommended doses or with continuous use for many years
Frequency not reported: Vertigo
Rare (Less than 0.1%): Rash, face edema, urticaria
Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.
Source: Drugs.com Cafergot