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Generic Name: cabozantinib (KA boe ZAN ti nib)
Brand Name: Cabometyx, Cometriq
Physician reviewed Cabometyx patient information - includes Cabometyx description, dosage and directions.
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Drug Information:
Cabometyx is used to treat advanced kidney cancer, or thyroid cancer that has spread to other parts of the body. Cabometyx is also used to treat liver cancer in people who have been previously treated with sorafenib (Nexavar). Cabometyx may also be used for purposes not listed in this medication guide. Cabometyx may cause a perforation (a hole or tear) or a fistula (an abnormal passageway) within your stomach or intestines. This medicine can also increase your risk of serious bleeding. Call your doctor if you have: severe stomach pain, choking or gagging when you eat or drink, unusual bleeding, bloody or tarry stools, heavy menstrual bleeding, or if you cough up blood. Learn more

Cabometyx Side Effects

Cabometyx Side Effects

Note: This document contains side effect information about cabozantinib. Some of the dosage forms listed on this page may not apply to the brand name Cabometyx.

For the Consumer

Applies to cabozantinib: oral capsule, oral tablet


Oral route (Capsule)

Gastrointestinal (GI) perforations, fistula formation, and severe hemorrhage have occurred in patients treated with cabozantinib malate. Discontinue therapy if GI perforation or fistula develop. Monitor patients for bleeding, and do not administer cabozantinib malate to patients with severe hemorrhage.

Along with its needed effects, cabozantinib (the active ingredient contained in Cabometyx) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cabozantinib:

More common

  • Blurred vision
  • burning, numbness, tingling, or painful sensations
  • dehydration
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • nervousness
  • pain in the chest, groin, or legs, especially the calves
  • pounding in the ears
  • redness, swelling, or pain of the skin
  • scaling of the skin on the hands and feet
  • severe, sudden headache
  • skin ulcers
  • slow or fast heartbeat
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • unsteadiness or awkwardness
  • vision changes
  • weakness in the arms, hands, legs, or feet

Less common

  • Bleeding gums
  • bloody, black, or tarry stools
  • coughing up blood
  • heartburn
  • heavy jaw feeling
  • increased menstrual flow or vaginal bleeding
  • indigestion
  • loosening of a tooth
  • nausea
  • nosebleeds
  • pain, swelling, or numbness in the mouth or jaw
  • paralysis
  • prolonged bleeding from cuts
  • red or dark brown urine
  • severe abdominal or stomach pain, cramping, or burning
  • trouble breathing
  • vomiting of material that looks like coffee grounds, severe and continuing


  • Confusion
  • disturbed color perception
  • double vision
  • halos around lights
  • night blindness
  • overbright appearance of lights
  • seizures
  • tunnel vision

Some side effects of cabozantinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Belching
  • bleeding after defecation
  • change in taste
  • changes in hair color
  • decreased appetite
  • decreased weight
  • diarrhea
  • difficulty having a bowel movement
  • difficulty with moving
  • dry skin
  • fear
  • hair loss or thinning of the hair
  • hoarseness
  • lack or loss of strength
  • loss of taste
  • muscle pain, spasm, or stiffness
  • pain in the joints
  • rash
  • sore throat
  • stomach discomfort, upset, or pain
  • swelling or inflammation of the mouth
  • uncomfortable swelling around the anus
  • voice changes
  • vomiting

For Healthcare Professionals

Applies to cabozantinib: oral capsule, oral tablet


Very common (10% or more): Elevated blood pressure (up to 96%), hypertension (up to 61%)

Common (1% to 10%): Hypotension, venous thromboembolism, arterial thromboembolism, atrial fibrillation

Uncommon (0.1% to 1%): Angina pectoris, supraventricular tachycardia, shortened activated partial thromboplastin time

Frequency not reported: QT interval prolongation


Very common (10% or more): Increased ALT (up to 86%), increased AST (up to 86%), increased alkaline phosphatase (up to 52%), hyperbilirubinemia (up to 25%)

Common (1% to 10%): Cholelithiasis

Uncommon (0.1% to 1%): Hepatic encephalopathy


Very common (10% or more): Diarrhea (up to 63%), stomatitis (up to 51%), nausea (up to 43%), oral pain (up to 36%), constipation (up to 27%), abdominal pain (up to 27%), vomiting (up to 24%), dysphagia (up to 13%), dyspepsia (up to 11%), glossodynia

Common (1% to 10%): Hemorrhoids, GI perforation, GI fistula, GI hemorrhage, pancreatitis, anal fissure, anal inflammation, cheilitis

Uncommon (0.1% to 1%): Esophagitis


Very common (10% or more): Increased blood thyroid stimulating hormone (up to 57%)

Common (1% to 10%): Hypothyroidism

Uncommon (0.1% to 1%): Amenorrhea


Very common (10% or more): Lymphopenia (up to 53%), neutropenia (up to 35%), thrombocytopenia (up to 35%)

Uncommon (0.1% to 1%): Increased eosinophil count, increased platelet count


Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (up to 50%), hair color changes/depigmentation/graying (up to 34%), rash (up to 19%), dry skin (up to 19%), alopecia (up to 16%), erythema (up to 11%)

Common (1% to 10%): Hyperkeratosis, folliculitis, acne, blister, abnormal hair growth, skin exfoliation, skin hypopigmentation

Uncommon (0.1% to 1%): Skin ulcer, telangiectasia


Very common (10% or more): Decreased weight (up to 48%), decreased appetite (up to 46%), hypocalcemia (up to 52%), hypophosphatemia (up to 28%), hypomagnesemia (up to 19%), hypokalemia (up to 18%), hyponatremia (up to 10%), increased blood lactate dehydrogenase, increased blood creatinine phosphokinase

Common (1% to 10%): Dehydration, hypoalbuminemia


Very common (10% or more): Fatigue (up to 41%), asthenia (up to 21%), mucosal inflammation

Common (1% to 10%): Abscess (including visceral, intra-abdominal, skin, tooth), fungal infection (including skin, oral, genital), ear pain, tinnitus, pallor, peripheral coldness, impaired wound healing/wound complications, chills, face edema

Uncommon (0.1% to 1%): Aspergilloma, hypoacusis, cyst, facial pain, localized edema

Frequency not reported: Hemorrhage

Nervous system

Very common (10% or more): Dysgeusia (up to 34%), headache (up to 18%), dizziness (up to 14%)

Common (1% to 10%): Paresthesia, peripheral sensory neuropathy, peripheral neuropathy, ageusia, tremor

Uncommon (0.1% to 1%): Reversible posterior leukoencephalopathy syndrome, ataxia, attention disturbance, loss of consciousness, speech disorder, transient ischemic attack


Very common (10% or more): Arthralgia (up to 14%), muscle spasms (up to 12%)

Common (1% to 10%): Musculoskeletal chest pain, osteonecrosis of the jaw (ONJ)

Uncommon (0.1% to 1%): Rhabdomyolysis


Patients should be closely monitored for the first 8 weeks as most adverse events have occurred early in the course of treatment.


Common (1% to 10%): Proteinuria, dysuria, hematuria

Uncommon (0.1% to 1%): Vaginal hemorrhage


Common (1% to 10%): Blurred vision

Uncommon (0.1% to 1%): Cataract, conjunctivitis


Common (1% to 10%): Anxiety, depression, confusional state

Uncommon (0.1% to 1%): Abnormal dreams, delirium


Very common (10% or more): Dysphonia (up to 20%), oropharyngeal pain

Common (1% to 10%): Non-GI fistula (including tracheal, pneumomediastinum, tracheo-esophageal), pulmonary embolism, respiratory tract hemorrhage (including pulmonary, bronchial, tracheal), pneumonia, pneumonia aspiration

Uncommon (0.1% to 1%): Atelectasis, pharyngeal edema, pneumonitis


Uncommon (0.1% to 1%): Acute renal failure

Editorial References and Review

Medically reviewed by BestRx Medical Team Last updated on 1/1/2020.

Source: Drugs.com Cabometyx